6UM8
HIV Integrase in complex with Compound-14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrase | polymer | 166 | 18121.6 | 2 | UniProt (Q76353) Pfam (PF00665) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | C, D, K, L (A, B) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 4 | Chemie (1PE) | |||
| 3 | E, F (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 4 | G, M (A, B) | (2S)-tert-butoxy[7-(8-fluoro-5-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid | non-polymer | 503.6 | 2 | Chemie (QCG) | |||
| 5 | H, I, J, N, O... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 6 | Q, R (A, B) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A, B: 57 - 212 (UniProt: Q76353)
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
| His 49 | - | expression tag |
| Met 50 | - | expression tag |
| His 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Gln 53 | - | expression tag |
| Val 54 | - | expression tag |
| Asp 55 | - | expression tag |
| Ser 56 | - | expression tag |
| Glu 131 | Trp 131 | conflict |
| Lys 185 | Phe 185 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36243.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2748.9 | |
| All* | Total formula weight | 38992.1 |
