6ULN

Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation

Summary for 6ULN

Entry DOI	10.2210/pdb6uln/pdb
Descriptor	HLA class I antigen, Beta-2-microglobulin, GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA, ... (9 entities in total)
Functional Keywords	hla-c neoantigen kras, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	95233.76
Authors	Sun, P.D.,Sim, M.J.W. (deposition date: 2019-10-08, release date: 2020-05-27, Last modification date: 2023-10-11)
Primary citation	Sim, M.J.W.,Lu, J.,Spencer, M.,Hopkins, F.,Tran, E.,Rosenberg, S.A.,Long, E.O.,Sun, P.D. High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D. Proc.Natl.Acad.Sci.USA, 117:12826-12835, 2020 Cited by PubMed: 32461371 DOI: 10.1073/pnas.1921964117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation