6ULN
Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | HLA class I antigen | polymer | 274 | 31837.1 | 1 | UniProt (C1K0Y1) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (Human) | MHC class I antigen,MHC class I histocompatibility antigen |
| 2 | B | Beta-2-microglobulin | polymer | 99 | 11748.2 | 1 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
| 3 | C | GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA | polymer | 9 | 761.8 | 1 | UniProt (P01111) In PDB | Homo sapiens | |
| 4 | D | TCR-V-alpha-4*01 | polymer | 206 | 22651.1 | 1 | Homo sapiens (Human) | ||
| 5 | E | TCR-V-beta-5-6*01 | polymer | 243 | 27442.3 | 1 | Homo sapiens (Human) | ||
| 6 | A, E | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 7 | A, B, D, E | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 8 | E | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 9 | water | water | 18.0 | 425 | Chemie (HOH) |
Sequence modifications
C: 1 - 9 (UniProt: P01111)
| PDB | External Database | Details |
|---|---|---|
| Asp 3 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94440.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 793.3 | |
| All* | Total formula weight | 95233.8 |
