6UC2

Human IMPDH2 treated with ATP and 2 mM GTP. Free canonical octamer reconstruction.

Summary for 6UC2

• Entry DOI: 10.2210/pdb6uc2/pdb
• EMDB information: 20725
• Descriptor: Inosine-5'-monophosphate dehydrogenase 2, GUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE (3 entities in total)
• Functional Keywords: metabolism, filament, allostery, adenine, guanine, biosynthetic protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 464272.33

Authors

Johnson, M.C.,Kollman, J.M. (deposition date: 2019-09-13, release date: 2020-03-25, Last modification date: 2024-03-20)

• Primary citation: Johnson, M.C.,Kollman, J.M.; Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation.; Elife, 9:-, 2020; PubMed: 31999252; DOI: 10.7554/eLife.53243

Experimental method

ELECTRON MICROSCOPY (4.48 Å)