Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UC2

Human IMPDH2 treated with ATP and 2 mM GTP. Free canonical octamer reconstruction.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005778	cellular_component	peroxisomal membrane
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0006183	biological_process	GTP biosynthetic process
A	0007623	biological_process	circadian rhythm
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0034774	cellular_component	secretory granule lumen
A	0046651	biological_process	lymphocyte proliferation
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071353	biological_process	cellular response to interleukin-4
A	0097294	biological_process	'de novo' XMP biosynthetic process
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0003938	molecular_function	IMP dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005778	cellular_component	peroxisomal membrane
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006177	biological_process	GMP biosynthetic process
B	0006183	biological_process	GTP biosynthetic process
B	0007623	biological_process	circadian rhythm
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0034774	cellular_component	secretory granule lumen
B	0046651	biological_process	lymphocyte proliferation
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0071353	biological_process	cellular response to interleukin-4
B	0097294	biological_process	'de novo' XMP biosynthetic process
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000166	molecular_function	nucleotide binding
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0003824	molecular_function	catalytic activity
C	0003938	molecular_function	IMP dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005778	cellular_component	peroxisomal membrane
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006177	biological_process	GMP biosynthetic process
C	0006183	biological_process	GTP biosynthetic process
C	0007623	biological_process	circadian rhythm
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0034774	cellular_component	secretory granule lumen
C	0046651	biological_process	lymphocyte proliferation
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0071353	biological_process	cellular response to interleukin-4
C	0097294	biological_process	'de novo' XMP biosynthetic process
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003723	molecular_function	RNA binding
D	0003824	molecular_function	catalytic activity
D	0003938	molecular_function	IMP dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005778	cellular_component	peroxisomal membrane
D	0005829	cellular_component	cytosol
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006177	biological_process	GMP biosynthetic process
D	0006183	biological_process	GTP biosynthetic process
D	0007623	biological_process	circadian rhythm
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0034774	cellular_component	secretory granule lumen
D	0046651	biological_process	lymphocyte proliferation
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0071353	biological_process	cellular response to interleukin-4
D	0097294	biological_process	'de novo' XMP biosynthetic process
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0000166	molecular_function	nucleotide binding
E	0003677	molecular_function	DNA binding
E	0003723	molecular_function	RNA binding
E	0003824	molecular_function	catalytic activity
E	0003938	molecular_function	IMP dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005778	cellular_component	peroxisomal membrane
E	0005829	cellular_component	cytosol
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006177	biological_process	GMP biosynthetic process
E	0006183	biological_process	GTP biosynthetic process
E	0007623	biological_process	circadian rhythm
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0034774	cellular_component	secretory granule lumen
E	0046651	biological_process	lymphocyte proliferation
E	0046872	molecular_function	metal ion binding
E	0070062	cellular_component	extracellular exosome
E	0071353	biological_process	cellular response to interleukin-4
E	0097294	biological_process	'de novo' XMP biosynthetic process
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000166	molecular_function	nucleotide binding
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0003824	molecular_function	catalytic activity
F	0003938	molecular_function	IMP dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005778	cellular_component	peroxisomal membrane
F	0005829	cellular_component	cytosol
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006177	biological_process	GMP biosynthetic process
F	0006183	biological_process	GTP biosynthetic process
F	0007623	biological_process	circadian rhythm
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0034774	cellular_component	secretory granule lumen
F	0046651	biological_process	lymphocyte proliferation
F	0046872	molecular_function	metal ion binding
F	0070062	cellular_component	extracellular exosome
F	0071353	biological_process	cellular response to interleukin-4
F	0097294	biological_process	'de novo' XMP biosynthetic process
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0000166	molecular_function	nucleotide binding
G	0003677	molecular_function	DNA binding
G	0003723	molecular_function	RNA binding
G	0003824	molecular_function	catalytic activity
G	0003938	molecular_function	IMP dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005778	cellular_component	peroxisomal membrane
G	0005829	cellular_component	cytosol
G	0006164	biological_process	purine nucleotide biosynthetic process
G	0006177	biological_process	GMP biosynthetic process
G	0006183	biological_process	GTP biosynthetic process
G	0007623	biological_process	circadian rhythm
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0034774	cellular_component	secretory granule lumen
G	0046651	biological_process	lymphocyte proliferation
G	0046872	molecular_function	metal ion binding
G	0070062	cellular_component	extracellular exosome
G	0071353	biological_process	cellular response to interleukin-4
G	0097294	biological_process	'de novo' XMP biosynthetic process
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0000166	molecular_function	nucleotide binding
H	0003677	molecular_function	DNA binding
H	0003723	molecular_function	RNA binding
H	0003824	molecular_function	catalytic activity
H	0003938	molecular_function	IMP dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005778	cellular_component	peroxisomal membrane
H	0005829	cellular_component	cytosol
H	0006164	biological_process	purine nucleotide biosynthetic process
H	0006177	biological_process	GMP biosynthetic process
H	0006183	biological_process	GTP biosynthetic process
H	0007623	biological_process	circadian rhythm
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0034774	cellular_component	secretory granule lumen
H	0046651	biological_process	lymphocyte proliferation
H	0046872	molecular_function	metal ion binding
H	0070062	cellular_component	extracellular exosome
H	0071353	biological_process	cellular response to interleukin-4
H	0097294	biological_process	'de novo' XMP biosynthetic process
H	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue GTP A 601

Chain	Residue
A	LYS109
A	THR225
A	ATP603
A	TYR110
A	GLN112
A	PRO118
A	PHE139
A	CYS140
A	GLY141
A	SER160
A	ARG224

site_id	AC2
Number of Residues	6
Details	binding site for residue GTP A 602

Chain	Residue
A	LEU194
A	LYS195
A	ASN198
A	ASP226
A	ASN230
A	LYS242

site_id	AC3
Number of Residues	11
Details	binding site for residue ATP A 603

Chain	Residue
A	ILE157
A	SER159
A	SER160
A	ARG161
A	ASP162
A	THR180
A	LEU185
A	VAL186
A	LYS206
A	LYS208
A	GTP601

site_id	AC4
Number of Residues	11
Details	binding site for residue GTP B 601

Chain	Residue
B	LYS109
B	TYR110
B	GLN112
B	PRO118
B	PHE139
B	CYS140
B	GLY141
B	SER160
B	ARG224
B	THR225
B	ATP603

site_id	AC5
Number of Residues	6
Details	binding site for residue GTP B 602

Chain	Residue
B	LEU194
B	LYS195
B	ASN198
B	ASP226
B	ASN230
B	LYS242

site_id	AC6
Number of Residues	11
Details	binding site for residue GTP C 601

Chain	Residue
C	LYS109
C	TYR110
C	GLN112
C	PRO118
C	PHE139
C	CYS140
C	GLY141
C	SER160
C	ARG224
C	THR225
C	ATP603

site_id	AC7
Number of Residues	6
Details	binding site for residue GTP C 602

Chain	Residue
C	LEU194
C	LYS195
C	ASN198
C	ASP226
C	ASN230
C	LYS242

site_id	AC8
Number of Residues	11
Details	binding site for residue GTP D 601

Chain	Residue
D	LYS109
D	TYR110
D	GLN112
D	PRO118
D	PHE139
D	CYS140
D	GLY141
D	SER160
D	ARG224
D	THR225
D	ATP603

site_id	AC9
Number of Residues	6
Details	binding site for residue GTP D 602

Chain	Residue
D	LEU194
D	LYS195
D	ASN198
D	ASP226
D	ASN230
D	LYS242

site_id	AD1
Number of Residues	11
Details	binding site for residue GTP E 601

Chain	Residue
E	LYS109
E	TYR110
E	GLN112
E	PRO118
E	PHE139
E	CYS140
E	GLY141
E	SER160
E	ARG224
E	THR225
E	ATP603

site_id	AD2
Number of Residues	6
Details	binding site for residue GTP E 602

Chain	Residue
E	LEU194
E	LYS195
E	ASN198
E	ASP226
E	ASN230
E	LYS242

site_id	AD3
Number of Residues	11
Details	binding site for residue GTP F 601

Chain	Residue
F	PRO118
F	PHE139
F	CYS140
F	GLY141
F	SER160
F	ARG224
F	THR225
F	ATP603
F	LYS109
F	TYR110
F	GLN112

site_id	AD4
Number of Residues	6
Details	binding site for residue GTP F 602

Chain	Residue
F	LEU194
F	LYS195
F	ASN198
F	ASP226
F	ASN230
F	LYS242

site_id	AD5
Number of Residues	11
Details	binding site for residue GTP G 601

Chain	Residue
G	LYS109
G	TYR110
G	GLN112
G	PRO118
G	PHE139
G	CYS140
G	GLY141
G	SER160
G	ARG224
G	THR225
G	ATP603

site_id	AD6
Number of Residues	6
Details	binding site for residue GTP G 602

Chain	Residue
G	LEU194
G	LYS195
G	ASN198
G	ASP226
G	ASN230
G	LYS242

site_id	AD7
Number of Residues	11
Details	binding site for residue GTP H 601

Chain	Residue
H	LYS109
H	TYR110
H	GLN112
H	PRO118
H	PHE139
H	CYS140
H	GLY141
H	SER160
H	ARG224
H	THR225
H	ATP603

site_id	AD8
Number of Residues	6
Details	binding site for residue GTP H 602

Chain	Residue
H	LEU194
H	LYS195
H	ASN198
H	ASP226
H	ASN230
H	LYS242

site_id	AD9
Number of Residues	14
Details	binding site for Di-peptide ATP B 603 and LYS B 208

Chain	Residue
B	ILE157
B	SER159
B	SER160
B	ARG161
B	ASP162
B	THR180
B	LEU185
B	VAL186
B	LYS206
B	GLY207
B	LEU209
B	ILE222
B	ARG224
B	GTP601

site_id	AE1
Number of Residues	14
Details	binding site for Di-peptide ATP B 603 and LYS B 208

Chain	Residue
B	ILE157
B	SER159
B	SER160
B	ARG161
B	ASP162
B	THR180
B	LEU185
B	VAL186
B	LYS206
B	GLY207
B	LEU209
B	ILE222
B	ARG224
B	GTP601

site_id	AE2
Number of Residues	14
Details	binding site for Di-peptide ATP C 603 and LYS C 208

Chain	Residue
C	ILE157
C	SER159
C	SER160
C	ARG161
C	ASP162
C	THR180
C	LEU185
C	VAL186
C	LYS206
C	GLY207
C	LEU209
C	ILE222
C	ARG224
C	GTP601

site_id	AE3
Number of Residues	14
Details	binding site for Di-peptide ATP C 603 and LYS C 208

Chain	Residue
C	ILE157
C	SER159
C	SER160
C	ARG161
C	ASP162
C	THR180
C	LEU185
C	VAL186
C	LYS206
C	GLY207
C	LEU209
C	ILE222
C	ARG224
C	GTP601

site_id	AE4
Number of Residues	14
Details	binding site for Di-peptide ATP D 603 and LYS D 208

Chain	Residue
D	ILE157
D	SER159
D	SER160
D	ARG161
D	ASP162
D	THR180
D	LEU185
D	VAL186
D	LYS206
D	GLY207
D	LEU209
D	ILE222
D	ARG224
D	GTP601

site_id	AE5
Number of Residues	14
Details	binding site for Di-peptide ATP D 603 and LYS D 208

Chain	Residue
D	ILE157
D	SER159
D	SER160
D	ARG161
D	ASP162
D	THR180
D	LEU185
D	VAL186
D	LYS206
D	GLY207
D	LEU209
D	ILE222
D	ARG224
D	GTP601

site_id	AE6
Number of Residues	14
Details	binding site for Di-peptide ATP E 603 and LYS E 208

Chain	Residue
E	ILE157
E	SER159
E	SER160
E	ARG161
E	ASP162
E	THR180
E	LEU185
E	VAL186
E	LYS206
E	GLY207
E	LEU209
E	ILE222
E	ARG224
E	GTP601

site_id	AE7
Number of Residues	14
Details	binding site for Di-peptide ATP E 603 and LYS E 208

Chain	Residue
E	ILE157
E	SER159
E	SER160
E	ARG161
E	ASP162
E	THR180
E	LEU185
E	VAL186
E	LYS206
E	GLY207
E	LEU209
E	ILE222
E	ARG224
E	GTP601

site_id	AE8
Number of Residues	14
Details	binding site for Di-peptide ATP F 603 and LYS F 208

Chain	Residue
F	ILE157
F	SER159
F	SER160
F	ARG161
F	ASP162
F	THR180
F	LEU185
F	VAL186
F	LYS206
F	GLY207
F	LEU209
F	ILE222
F	ARG224
F	GTP601

site_id	AE9
Number of Residues	14
Details	binding site for Di-peptide ATP F 603 and LYS F 208

Chain	Residue
F	ILE157
F	SER159
F	SER160
F	ARG161
F	ASP162
F	THR180
F	LEU185
F	VAL186
F	LYS206
F	GLY207
F	LEU209
F	ILE222
F	ARG224
F	GTP601

site_id	AF1
Number of Residues	14
Details	binding site for Di-peptide ATP G 603 and LYS G 208

Chain	Residue
G	ILE157
G	SER159
G	SER160
G	ARG161
G	ASP162
G	THR180
G	LEU185
G	VAL186
G	LYS206
G	GLY207
G	LEU209
G	ILE222
G	ARG224
G	GTP601

site_id	AF2
Number of Residues	14
Details	binding site for Di-peptide ATP G 603 and LYS G 208

Chain	Residue
G	ILE157
G	SER159
G	SER160
G	ARG161
G	ASP162
G	THR180
G	LEU185
G	VAL186
G	LYS206
G	GLY207
G	LEU209
G	ILE222
G	ARG224
G	GTP601

site_id	AF3
Number of Residues	14
Details	binding site for Di-peptide ATP H 603 and LYS H 208

Chain	Residue
H	ILE157
H	SER159
H	SER160
H	ARG161
H	ASP162
H	THR180
H	LEU185
H	VAL186
H	LYS206
H	GLY207
H	LEU209
H	ILE222
H	ARG224
H	GTP601

site_id	AF4
Number of Residues	14
Details	binding site for Di-peptide ATP H 603 and LYS H 208

Chain	Residue
H	ILE157
H	SER159
H	SER160
H	ARG161
H	ASP162
H	THR180
H	LEU185
H	VAL186
H	LYS206
H	GLY207
H	LEU209
H	ILE222
H	ARG224
H	GTP601

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGsGSICiT

Chain	Residue	Details
A	LEU321-THR333

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	472
Details	Domain: {"description":"CBS 1","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	464
Details	Domain: {"description":"CBS 2","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2002","submissionDatabase":"PDB data bank","title":"Crystal structure of human inosine monophosphate dehydrogenase type II complexed with the MPA/NAD analog C2-MAD.","authors":["Risal D.","Strickler M.D.","Goldstein B.M."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)