6UA5
Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free interfacial octamer reconstruction.
Summary for 6UA5
| Entry DOI | 10.2210/pdb6ua5/pdb |
| Related | 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 |
| EMDB information | 20687 20688 20690 20691 20701 20704 20705 20706 |
| Descriptor | Inosine-5'-monophosphate dehydrogenase 2, INOSINIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total) |
| Functional Keywords | metabolism, filament, allostery, adenine, guanine, biosynthetic protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 8 |
| Total formula weight | 459937.05 |
| Authors | Johnson, M.C.,Kollman, J.M. (deposition date: 2019-09-10, release date: 2020-03-25, Last modification date: 2024-03-20) |
| Primary citation | Johnson, M.C.,Kollman, J.M. Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9:-, 2020 Cited by PubMed: 31999252DOI: 10.7554/eLife.53243 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.79 Å) |
Structure validation
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