6UA5
Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free interfacial octamer reconstruction.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003677 | molecular_function | DNA binding |
A | 0003723 | molecular_function | RNA binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0003938 | molecular_function | IMP dehydrogenase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005778 | cellular_component | peroxisomal membrane |
A | 0005829 | cellular_component | cytosol |
A | 0006164 | biological_process | purine nucleotide biosynthetic process |
A | 0006177 | biological_process | GMP biosynthetic process |
A | 0006183 | biological_process | GTP biosynthetic process |
A | 0007623 | biological_process | circadian rhythm |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0034774 | cellular_component | secretory granule lumen |
A | 0046651 | biological_process | lymphocyte proliferation |
A | 0046872 | molecular_function | metal ion binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0071353 | biological_process | cellular response to interleukin-4 |
A | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003677 | molecular_function | DNA binding |
B | 0003723 | molecular_function | RNA binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0003938 | molecular_function | IMP dehydrogenase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005778 | cellular_component | peroxisomal membrane |
B | 0005829 | cellular_component | cytosol |
B | 0006164 | biological_process | purine nucleotide biosynthetic process |
B | 0006177 | biological_process | GMP biosynthetic process |
B | 0006183 | biological_process | GTP biosynthetic process |
B | 0007623 | biological_process | circadian rhythm |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0034774 | cellular_component | secretory granule lumen |
B | 0046651 | biological_process | lymphocyte proliferation |
B | 0046872 | molecular_function | metal ion binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0071353 | biological_process | cellular response to interleukin-4 |
B | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
C | 0000166 | molecular_function | nucleotide binding |
C | 0003677 | molecular_function | DNA binding |
C | 0003723 | molecular_function | RNA binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0003938 | molecular_function | IMP dehydrogenase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005778 | cellular_component | peroxisomal membrane |
C | 0005829 | cellular_component | cytosol |
C | 0006164 | biological_process | purine nucleotide biosynthetic process |
C | 0006177 | biological_process | GMP biosynthetic process |
C | 0006183 | biological_process | GTP biosynthetic process |
C | 0007623 | biological_process | circadian rhythm |
C | 0016020 | cellular_component | membrane |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0034774 | cellular_component | secretory granule lumen |
C | 0046651 | biological_process | lymphocyte proliferation |
C | 0046872 | molecular_function | metal ion binding |
C | 0070062 | cellular_component | extracellular exosome |
C | 0071353 | biological_process | cellular response to interleukin-4 |
C | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
C | 1904813 | cellular_component | ficolin-1-rich granule lumen |
D | 0000166 | molecular_function | nucleotide binding |
D | 0003677 | molecular_function | DNA binding |
D | 0003723 | molecular_function | RNA binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0003938 | molecular_function | IMP dehydrogenase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005576 | cellular_component | extracellular region |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0005778 | cellular_component | peroxisomal membrane |
D | 0005829 | cellular_component | cytosol |
D | 0006164 | biological_process | purine nucleotide biosynthetic process |
D | 0006177 | biological_process | GMP biosynthetic process |
D | 0006183 | biological_process | GTP biosynthetic process |
D | 0007623 | biological_process | circadian rhythm |
D | 0016020 | cellular_component | membrane |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0034774 | cellular_component | secretory granule lumen |
D | 0046651 | biological_process | lymphocyte proliferation |
D | 0046872 | molecular_function | metal ion binding |
D | 0070062 | cellular_component | extracellular exosome |
D | 0071353 | biological_process | cellular response to interleukin-4 |
D | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
E | 0000166 | molecular_function | nucleotide binding |
E | 0003677 | molecular_function | DNA binding |
E | 0003723 | molecular_function | RNA binding |
E | 0003824 | molecular_function | catalytic activity |
E | 0003938 | molecular_function | IMP dehydrogenase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005576 | cellular_component | extracellular region |
E | 0005634 | cellular_component | nucleus |
E | 0005737 | cellular_component | cytoplasm |
E | 0005778 | cellular_component | peroxisomal membrane |
E | 0005829 | cellular_component | cytosol |
E | 0006164 | biological_process | purine nucleotide biosynthetic process |
E | 0006177 | biological_process | GMP biosynthetic process |
E | 0006183 | biological_process | GTP biosynthetic process |
E | 0007623 | biological_process | circadian rhythm |
E | 0016020 | cellular_component | membrane |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0034774 | cellular_component | secretory granule lumen |
E | 0046651 | biological_process | lymphocyte proliferation |
E | 0046872 | molecular_function | metal ion binding |
E | 0070062 | cellular_component | extracellular exosome |
E | 0071353 | biological_process | cellular response to interleukin-4 |
E | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
E | 1904813 | cellular_component | ficolin-1-rich granule lumen |
F | 0000166 | molecular_function | nucleotide binding |
F | 0003677 | molecular_function | DNA binding |
F | 0003723 | molecular_function | RNA binding |
F | 0003824 | molecular_function | catalytic activity |
F | 0003938 | molecular_function | IMP dehydrogenase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005576 | cellular_component | extracellular region |
F | 0005634 | cellular_component | nucleus |
F | 0005737 | cellular_component | cytoplasm |
F | 0005778 | cellular_component | peroxisomal membrane |
F | 0005829 | cellular_component | cytosol |
F | 0006164 | biological_process | purine nucleotide biosynthetic process |
F | 0006177 | biological_process | GMP biosynthetic process |
F | 0006183 | biological_process | GTP biosynthetic process |
F | 0007623 | biological_process | circadian rhythm |
F | 0016020 | cellular_component | membrane |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0034774 | cellular_component | secretory granule lumen |
F | 0046651 | biological_process | lymphocyte proliferation |
F | 0046872 | molecular_function | metal ion binding |
F | 0070062 | cellular_component | extracellular exosome |
F | 0071353 | biological_process | cellular response to interleukin-4 |
F | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
F | 1904813 | cellular_component | ficolin-1-rich granule lumen |
G | 0000166 | molecular_function | nucleotide binding |
G | 0003677 | molecular_function | DNA binding |
G | 0003723 | molecular_function | RNA binding |
G | 0003824 | molecular_function | catalytic activity |
G | 0003938 | molecular_function | IMP dehydrogenase activity |
G | 0005515 | molecular_function | protein binding |
G | 0005576 | cellular_component | extracellular region |
G | 0005634 | cellular_component | nucleus |
G | 0005737 | cellular_component | cytoplasm |
G | 0005778 | cellular_component | peroxisomal membrane |
G | 0005829 | cellular_component | cytosol |
G | 0006164 | biological_process | purine nucleotide biosynthetic process |
G | 0006177 | biological_process | GMP biosynthetic process |
G | 0006183 | biological_process | GTP biosynthetic process |
G | 0007623 | biological_process | circadian rhythm |
G | 0016020 | cellular_component | membrane |
G | 0016491 | molecular_function | oxidoreductase activity |
G | 0034774 | cellular_component | secretory granule lumen |
G | 0046651 | biological_process | lymphocyte proliferation |
G | 0046872 | molecular_function | metal ion binding |
G | 0070062 | cellular_component | extracellular exosome |
G | 0071353 | biological_process | cellular response to interleukin-4 |
G | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
G | 1904813 | cellular_component | ficolin-1-rich granule lumen |
H | 0000166 | molecular_function | nucleotide binding |
H | 0003677 | molecular_function | DNA binding |
H | 0003723 | molecular_function | RNA binding |
H | 0003824 | molecular_function | catalytic activity |
H | 0003938 | molecular_function | IMP dehydrogenase activity |
H | 0005515 | molecular_function | protein binding |
H | 0005576 | cellular_component | extracellular region |
H | 0005634 | cellular_component | nucleus |
H | 0005737 | cellular_component | cytoplasm |
H | 0005778 | cellular_component | peroxisomal membrane |
H | 0005829 | cellular_component | cytosol |
H | 0006164 | biological_process | purine nucleotide biosynthetic process |
H | 0006177 | biological_process | GMP biosynthetic process |
H | 0006183 | biological_process | GTP biosynthetic process |
H | 0007623 | biological_process | circadian rhythm |
H | 0016020 | cellular_component | membrane |
H | 0016491 | molecular_function | oxidoreductase activity |
H | 0034774 | cellular_component | secretory granule lumen |
H | 0046651 | biological_process | lymphocyte proliferation |
H | 0046872 | molecular_function | metal ion binding |
H | 0070062 | cellular_component | extracellular exosome |
H | 0071353 | biological_process | cellular response to interleukin-4 |
H | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
H | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | binding site for residue IMP A 601 |
Chain | Residue |
A | SER68 |
A | SER388 |
A | TYR411 |
A | GLY413 |
A | MET414 |
A | GLY415 |
A | GLN441 |
A | NAD602 |
A | MET70 |
A | ARG322 |
A | GLY328 |
A | SER329 |
A | CYS331 |
A | ASP364 |
A | GLY365 |
A | GLY387 |
site_id | AC2 |
Number of Residues | 15 |
Details | binding site for residue NAD A 602 |
Chain | Residue |
A | HIS93 |
A | THR252 |
A | HIS253 |
A | ASP274 |
A | SER276 |
A | PHE282 |
A | ASN303 |
A | ARG322 |
A | GLY324 |
A | MET325 |
A | MET414 |
A | GLN441 |
A | IMP601 |
D | THR45 |
D | GLN469 |
site_id | AC3 |
Number of Residues | 15 |
Details | binding site for residue NAD B 602 |
Chain | Residue |
A | THR45 |
A | GLN469 |
B | HIS93 |
B | THR252 |
B | HIS253 |
B | ASP274 |
B | SER276 |
B | PHE282 |
B | ASN303 |
B | ARG322 |
B | GLY324 |
B | MET325 |
B | MET414 |
B | GLN441 |
B | IMP601 |
site_id | AC4 |
Number of Residues | 15 |
Details | binding site for residue NAD C 602 |
Chain | Residue |
B | THR45 |
B | GLN469 |
C | HIS93 |
C | THR252 |
C | HIS253 |
C | ASP274 |
C | SER276 |
C | PHE282 |
C | ASN303 |
C | ARG322 |
C | GLY324 |
C | MET325 |
C | MET414 |
C | GLN441 |
C | IMP601 |
site_id | AC5 |
Number of Residues | 15 |
Details | binding site for residue NAD D 602 |
Chain | Residue |
C | THR45 |
C | GLN469 |
D | HIS93 |
D | THR252 |
D | HIS253 |
D | ASP274 |
D | SER276 |
D | PHE282 |
D | ASN303 |
D | ARG322 |
D | GLY324 |
D | MET325 |
D | MET414 |
D | GLN441 |
D | IMP601 |
site_id | AC6 |
Number of Residues | 15 |
Details | binding site for residue NAD E 602 |
Chain | Residue |
E | HIS93 |
E | THR252 |
E | HIS253 |
E | ASP274 |
E | SER276 |
E | PHE282 |
E | ASN303 |
E | ARG322 |
E | GLY324 |
E | MET325 |
E | MET414 |
E | GLN441 |
E | IMP601 |
H | THR45 |
H | GLN469 |
site_id | AC7 |
Number of Residues | 15 |
Details | binding site for residue NAD F 602 |
Chain | Residue |
F | ASN303 |
F | ARG322 |
F | GLY324 |
F | MET325 |
F | MET414 |
F | GLN441 |
F | IMP601 |
E | THR45 |
E | GLN469 |
F | HIS93 |
F | THR252 |
F | HIS253 |
F | ASP274 |
F | SER276 |
F | PHE282 |
site_id | AC8 |
Number of Residues | 15 |
Details | binding site for residue NAD G 602 |
Chain | Residue |
F | THR45 |
F | GLN469 |
G | HIS93 |
G | THR252 |
G | HIS253 |
G | ASP274 |
G | SER276 |
G | PHE282 |
G | ASN303 |
G | ARG322 |
G | GLY324 |
G | MET325 |
G | MET414 |
G | GLN441 |
G | IMP601 |
site_id | AC9 |
Number of Residues | 15 |
Details | binding site for residue NAD H 602 |
Chain | Residue |
G | THR45 |
G | GLN469 |
H | HIS93 |
H | THR252 |
H | HIS253 |
H | ASP274 |
H | SER276 |
H | PHE282 |
H | ASN303 |
H | ARG322 |
H | GLY324 |
H | MET325 |
H | MET414 |
H | GLN441 |
H | IMP601 |
site_id | AD1 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP B 601 and CYS B 331 |
Chain | Residue |
A | GLY501 |
A | GLY502 |
B | SER68 |
B | MET70 |
B | ARG322 |
B | GLY328 |
B | SER329 |
B | ILE330 |
B | ILE332 |
B | THR333 |
B | ASP364 |
B | GLY365 |
B | GLY387 |
B | SER388 |
B | TYR411 |
B | GLY413 |
B | MET414 |
B | GLY415 |
B | GLN441 |
B | NAD602 |
site_id | AD2 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP B 601 and CYS B 331 |
Chain | Residue |
A | GLY501 |
A | GLY502 |
B | SER68 |
B | MET70 |
B | ARG322 |
B | GLY328 |
B | SER329 |
B | ILE330 |
B | ILE332 |
B | THR333 |
B | ASP364 |
B | GLY365 |
B | GLY387 |
B | SER388 |
B | TYR411 |
B | GLY413 |
B | MET414 |
B | GLY415 |
B | GLN441 |
B | NAD602 |
site_id | AD3 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP C 601 and CYS C 331 |
Chain | Residue |
B | GLY501 |
B | GLY502 |
C | SER68 |
C | MET70 |
C | ARG322 |
C | GLY328 |
C | SER329 |
C | ILE330 |
C | ILE332 |
C | THR333 |
C | ASP364 |
C | GLY365 |
C | GLY387 |
C | SER388 |
C | TYR411 |
C | GLY413 |
C | MET414 |
C | GLY415 |
C | GLN441 |
C | NAD602 |
site_id | AD4 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP C 601 and CYS C 331 |
Chain | Residue |
B | GLY501 |
B | GLY502 |
C | SER68 |
C | MET70 |
C | ARG322 |
C | GLY328 |
C | SER329 |
C | ILE330 |
C | ILE332 |
C | THR333 |
C | ASP364 |
C | GLY365 |
C | GLY387 |
C | SER388 |
C | TYR411 |
C | GLY413 |
C | MET414 |
C | GLY415 |
C | GLN441 |
C | NAD602 |
site_id | AD5 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP D 601 and CYS D 331 |
Chain | Residue |
C | GLY501 |
C | GLY502 |
D | SER68 |
D | MET70 |
D | ARG322 |
D | GLY328 |
D | SER329 |
D | ILE330 |
D | ILE332 |
D | THR333 |
D | ASP364 |
D | GLY365 |
D | GLY387 |
D | SER388 |
D | TYR411 |
D | GLY413 |
D | MET414 |
D | GLY415 |
D | GLN441 |
D | NAD602 |
site_id | AD6 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP D 601 and CYS D 331 |
Chain | Residue |
C | GLY501 |
C | GLY502 |
D | SER68 |
D | MET70 |
D | ARG322 |
D | GLY328 |
D | SER329 |
D | ILE330 |
D | ILE332 |
D | THR333 |
D | ASP364 |
D | GLY365 |
D | GLY387 |
D | SER388 |
D | TYR411 |
D | GLY413 |
D | MET414 |
D | GLY415 |
D | GLN441 |
D | NAD602 |
site_id | AD7 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP E 601 and CYS E 331 |
Chain | Residue |
E | SER68 |
E | MET70 |
E | ARG322 |
E | GLY328 |
E | SER329 |
E | ILE330 |
E | ILE332 |
E | THR333 |
E | ASP364 |
E | GLY365 |
E | GLY387 |
E | SER388 |
E | TYR411 |
E | GLY413 |
E | MET414 |
E | GLY415 |
E | GLN441 |
E | NAD602 |
H | GLY501 |
H | GLY502 |
site_id | AD8 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP E 601 and CYS E 331 |
Chain | Residue |
E | SER68 |
E | MET70 |
E | ARG322 |
E | GLY328 |
E | SER329 |
E | ILE330 |
E | ILE332 |
E | THR333 |
E | ASP364 |
E | GLY365 |
E | GLY387 |
E | SER388 |
E | TYR411 |
E | GLY413 |
E | MET414 |
E | GLY415 |
E | GLN441 |
E | NAD602 |
H | GLY501 |
H | GLY502 |
site_id | AD9 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP F 601 and CYS F 331 |
Chain | Residue |
E | GLY501 |
E | GLY502 |
F | SER68 |
F | MET70 |
F | ARG322 |
F | GLY328 |
F | SER329 |
F | ILE330 |
F | ILE332 |
F | THR333 |
F | ASP364 |
F | GLY365 |
F | GLY387 |
F | SER388 |
F | TYR411 |
F | GLY413 |
F | MET414 |
F | GLY415 |
F | GLN441 |
F | NAD602 |
site_id | AE1 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP F 601 and CYS F 331 |
Chain | Residue |
E | GLY501 |
E | GLY502 |
F | SER68 |
F | MET70 |
F | ARG322 |
F | GLY328 |
F | SER329 |
F | ILE330 |
F | ILE332 |
F | THR333 |
F | ASP364 |
F | GLY365 |
F | GLY387 |
F | SER388 |
F | TYR411 |
F | GLY413 |
F | MET414 |
F | GLY415 |
F | GLN441 |
F | NAD602 |
site_id | AE2 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP G 601 and CYS G 331 |
Chain | Residue |
F | GLY501 |
F | GLY502 |
G | SER68 |
G | MET70 |
G | ARG322 |
G | GLY328 |
G | SER329 |
G | ILE330 |
G | ILE332 |
G | THR333 |
G | ASP364 |
G | GLY365 |
G | GLY387 |
G | SER388 |
G | TYR411 |
G | GLY413 |
G | MET414 |
G | GLY415 |
G | GLN441 |
G | NAD602 |
site_id | AE3 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP G 601 and CYS G 331 |
Chain | Residue |
F | GLY501 |
F | GLY502 |
G | SER68 |
G | MET70 |
G | ARG322 |
G | GLY328 |
G | SER329 |
G | ILE330 |
G | ILE332 |
G | THR333 |
G | ASP364 |
G | GLY365 |
G | GLY387 |
G | SER388 |
G | TYR411 |
G | GLY413 |
G | MET414 |
G | GLY415 |
G | GLN441 |
G | NAD602 |
site_id | AE4 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP H 601 and CYS H 331 |
Chain | Residue |
G | GLY501 |
G | GLY502 |
H | SER68 |
H | MET70 |
H | ARG322 |
H | GLY328 |
H | SER329 |
H | ILE330 |
H | ILE332 |
H | THR333 |
H | ASP364 |
H | GLY365 |
H | GLY387 |
H | SER388 |
H | TYR411 |
H | GLY413 |
H | MET414 |
H | GLY415 |
H | GLN441 |
H | NAD602 |
site_id | AE5 |
Number of Residues | 20 |
Details | binding site for Di-peptide IMP H 601 and CYS H 331 |
Chain | Residue |
G | GLY501 |
G | GLY502 |
H | SER68 |
H | MET70 |
H | ARG322 |
H | GLY328 |
H | SER329 |
H | ILE330 |
H | ILE332 |
H | THR333 |
H | ASP364 |
H | GLY365 |
H | GLY387 |
H | SER388 |
H | TYR411 |
H | GLY413 |
H | MET414 |
H | GLY415 |
H | GLN441 |
H | NAD602 |
Functional Information from PROSITE/UniProt
site_id | PS00487 |
Number of Residues | 13 |
Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGsGSICiT |
Chain | Residue | Details |
A | LEU321-THR333 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:10097070 |
Chain | Residue | Details |
A | CYS331 | |
B | CYS331 | |
C | CYS331 | |
D | CYS331 | |
E | CYS331 | |
F | CYS331 | |
G | CYS331 | |
H | CYS331 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03156 |
Chain | Residue | Details |
A | ARG429 | |
B | ARG429 | |
C | ARG429 | |
D | ARG429 | |
E | ARG429 | |
F | ARG429 | |
G | ARG429 | |
H | ARG429 |
site_id | SWS_FT_FI3 |
Number of Residues | 24 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP274 | |
D | ASP274 | |
D | ASP364 | |
D | GLY387 | |
E | ASP274 | |
E | ASP364 | |
E | GLY387 | |
F | ASP274 | |
F | ASP364 | |
F | GLY387 | |
G | ASP274 | |
A | ASP364 | |
G | ASP364 | |
G | GLY387 | |
H | ASP274 | |
H | ASP364 | |
H | GLY387 | |
A | GLY387 | |
B | ASP274 | |
B | ASP364 | |
B | GLY387 | |
C | ASP274 | |
C | ASP364 | |
C | GLY387 |
site_id | SWS_FT_FI4 |
Number of Residues | 56 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03156 |
Chain | Residue | Details |
A | GLY324 | |
B | TYR411 | |
B | GLN441 | |
B | GLU500 | |
B | GLY501 | |
B | GLY502 | |
C | GLY324 | |
C | SER329 | |
C | TYR411 | |
C | GLN441 | |
C | GLU500 | |
A | SER329 | |
C | GLY501 | |
C | GLY502 | |
D | GLY324 | |
D | SER329 | |
D | TYR411 | |
D | GLN441 | |
D | GLU500 | |
D | GLY501 | |
D | GLY502 | |
E | GLY324 | |
A | TYR411 | |
E | SER329 | |
E | TYR411 | |
E | GLN441 | |
E | GLU500 | |
E | GLY501 | |
E | GLY502 | |
F | GLY324 | |
F | SER329 | |
F | TYR411 | |
F | GLN441 | |
A | GLN441 | |
F | GLU500 | |
F | GLY501 | |
F | GLY502 | |
G | GLY324 | |
G | SER329 | |
G | TYR411 | |
G | GLN441 | |
G | GLU500 | |
G | GLY501 | |
G | GLY502 | |
A | GLU500 | |
H | GLY324 | |
H | SER329 | |
H | TYR411 | |
H | GLN441 | |
H | GLU500 | |
H | GLY501 | |
H | GLY502 | |
A | GLY501 | |
A | GLY502 | |
B | GLY324 | |
B | SER329 |
site_id | SWS_FT_FI5 |
Number of Residues | 24 |
Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|Ref.28 |
Chain | Residue | Details |
A | GLY326 | |
D | GLY326 | |
D | GLY328 | |
D | CYS331 | |
E | GLY326 | |
E | GLY328 | |
E | CYS331 | |
F | GLY326 | |
F | GLY328 | |
F | CYS331 | |
G | GLY326 | |
A | GLY328 | |
G | GLY328 | |
G | CYS331 | |
H | GLY326 | |
H | GLY328 | |
H | CYS331 | |
A | CYS331 | |
B | GLY326 | |
B | GLY328 | |
B | CYS331 | |
C | GLY326 | |
C | GLY328 | |
C | CYS331 |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER122 | |
B | SER122 | |
C | SER122 | |
D | SER122 | |
E | SER122 | |
F | SER122 | |
G | SER122 | |
H | SER122 |
site_id | SWS_FT_FI7 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER160 | |
B | SER160 | |
C | SER160 | |
D | SER160 | |
E | SER160 | |
F | SER160 | |
G | SER160 | |
H | SER160 |
site_id | SWS_FT_FI8 |
Number of Residues | 8 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
Chain | Residue | Details |
A | TYR400 | |
B | TYR400 | |
C | TYR400 | |
D | TYR400 | |
E | TYR400 | |
F | TYR400 | |
G | TYR400 | |
H | TYR400 |
site_id | SWS_FT_FI9 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER416 | |
B | SER416 | |
C | SER416 | |
D | SER416 | |
E | SER416 | |
F | SER416 | |
G | SER416 | |
H | SER416 |
site_id | SWS_FT_FI10 |
Number of Residues | 8 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS511 | |
B | LYS511 | |
C | LYS511 | |
D | LYS511 | |
E | LYS511 | |
F | LYS511 | |
G | LYS511 | |
H | LYS511 |
site_id | SWS_FT_FI11 |
Number of Residues | 32 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS195 | |
C | LYS208 | |
C | LYS438 | |
D | LYS195 | |
D | LYS208 | |
D | LYS438 | |
E | LYS195 | |
E | LYS208 | |
E | LYS438 | |
F | LYS195 | |
F | LYS208 | |
F | LYS438 | |
G | LYS195 | |
G | LYS208 | |
G | LYS438 | |
H | LYS195 | |
A | LYS208 | |
H | LYS208 | |
H | LYS438 | |
A | LYS438 | |
B | LYS195 | |
B | LYS208 | |
B | LYS438 | |
C | LYS195 |