6UA5
Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free interfacial octamer reconstruction.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003938 | molecular_function | IMP dehydrogenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005778 | cellular_component | peroxisomal membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003938 | molecular_function | IMP dehydrogenase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005778 | cellular_component | peroxisomal membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0007623 | biological_process | circadian rhythm |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0034774 | cellular_component | secretory granule lumen |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003938 | molecular_function | IMP dehydrogenase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005778 | cellular_component | peroxisomal membrane |
| C | 0005829 | cellular_component | cytosol |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0006177 | biological_process | GMP biosynthetic process |
| C | 0006183 | biological_process | GTP biosynthetic process |
| C | 0007623 | biological_process | circadian rhythm |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0034774 | cellular_component | secretory granule lumen |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| C | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003938 | molecular_function | IMP dehydrogenase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005778 | cellular_component | peroxisomal membrane |
| D | 0005829 | cellular_component | cytosol |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0006177 | biological_process | GMP biosynthetic process |
| D | 0006183 | biological_process | GTP biosynthetic process |
| D | 0007623 | biological_process | circadian rhythm |
| D | 0016020 | cellular_component | membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0034774 | cellular_component | secretory granule lumen |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003723 | molecular_function | RNA binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0003938 | molecular_function | IMP dehydrogenase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005778 | cellular_component | peroxisomal membrane |
| E | 0005829 | cellular_component | cytosol |
| E | 0006164 | biological_process | purine nucleotide biosynthetic process |
| E | 0006177 | biological_process | GMP biosynthetic process |
| E | 0006183 | biological_process | GTP biosynthetic process |
| E | 0007623 | biological_process | circadian rhythm |
| E | 0016020 | cellular_component | membrane |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0034774 | cellular_component | secretory granule lumen |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| E | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003723 | molecular_function | RNA binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0003938 | molecular_function | IMP dehydrogenase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005778 | cellular_component | peroxisomal membrane |
| F | 0005829 | cellular_component | cytosol |
| F | 0006164 | biological_process | purine nucleotide biosynthetic process |
| F | 0006177 | biological_process | GMP biosynthetic process |
| F | 0006183 | biological_process | GTP biosynthetic process |
| F | 0007623 | biological_process | circadian rhythm |
| F | 0016020 | cellular_component | membrane |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0034774 | cellular_component | secretory granule lumen |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| F | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0003677 | molecular_function | DNA binding |
| G | 0003723 | molecular_function | RNA binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0003938 | molecular_function | IMP dehydrogenase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005576 | cellular_component | extracellular region |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005778 | cellular_component | peroxisomal membrane |
| G | 0005829 | cellular_component | cytosol |
| G | 0006164 | biological_process | purine nucleotide biosynthetic process |
| G | 0006177 | biological_process | GMP biosynthetic process |
| G | 0006183 | biological_process | GTP biosynthetic process |
| G | 0007623 | biological_process | circadian rhythm |
| G | 0016020 | cellular_component | membrane |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0034774 | cellular_component | secretory granule lumen |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| G | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0003677 | molecular_function | DNA binding |
| H | 0003723 | molecular_function | RNA binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0003938 | molecular_function | IMP dehydrogenase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005576 | cellular_component | extracellular region |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005778 | cellular_component | peroxisomal membrane |
| H | 0005829 | cellular_component | cytosol |
| H | 0006164 | biological_process | purine nucleotide biosynthetic process |
| H | 0006177 | biological_process | GMP biosynthetic process |
| H | 0006183 | biological_process | GTP biosynthetic process |
| H | 0007623 | biological_process | circadian rhythm |
| H | 0016020 | cellular_component | membrane |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0034774 | cellular_component | secretory granule lumen |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0070062 | cellular_component | extracellular exosome |
| H | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| H | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue IMP A 601 |
| Chain | Residue |
| A | SER68 |
| A | SER388 |
| A | TYR411 |
| A | GLY413 |
| A | MET414 |
| A | GLY415 |
| A | GLN441 |
| A | NAD602 |
| A | MET70 |
| A | ARG322 |
| A | GLY328 |
| A | SER329 |
| A | CYS331 |
| A | ASP364 |
| A | GLY365 |
| A | GLY387 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue NAD A 602 |
| Chain | Residue |
| A | HIS93 |
| A | THR252 |
| A | HIS253 |
| A | ASP274 |
| A | SER276 |
| A | PHE282 |
| A | ASN303 |
| A | ARG322 |
| A | GLY324 |
| A | MET325 |
| A | MET414 |
| A | GLN441 |
| A | IMP601 |
| D | THR45 |
| D | GLN469 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue NAD B 602 |
| Chain | Residue |
| A | THR45 |
| A | GLN469 |
| B | HIS93 |
| B | THR252 |
| B | HIS253 |
| B | ASP274 |
| B | SER276 |
| B | PHE282 |
| B | ASN303 |
| B | ARG322 |
| B | GLY324 |
| B | MET325 |
| B | MET414 |
| B | GLN441 |
| B | IMP601 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue NAD C 602 |
| Chain | Residue |
| B | THR45 |
| B | GLN469 |
| C | HIS93 |
| C | THR252 |
| C | HIS253 |
| C | ASP274 |
| C | SER276 |
| C | PHE282 |
| C | ASN303 |
| C | ARG322 |
| C | GLY324 |
| C | MET325 |
| C | MET414 |
| C | GLN441 |
| C | IMP601 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue NAD D 602 |
| Chain | Residue |
| C | THR45 |
| C | GLN469 |
| D | HIS93 |
| D | THR252 |
| D | HIS253 |
| D | ASP274 |
| D | SER276 |
| D | PHE282 |
| D | ASN303 |
| D | ARG322 |
| D | GLY324 |
| D | MET325 |
| D | MET414 |
| D | GLN441 |
| D | IMP601 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue NAD E 602 |
| Chain | Residue |
| E | HIS93 |
| E | THR252 |
| E | HIS253 |
| E | ASP274 |
| E | SER276 |
| E | PHE282 |
| E | ASN303 |
| E | ARG322 |
| E | GLY324 |
| E | MET325 |
| E | MET414 |
| E | GLN441 |
| E | IMP601 |
| H | THR45 |
| H | GLN469 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue NAD F 602 |
| Chain | Residue |
| F | ASN303 |
| F | ARG322 |
| F | GLY324 |
| F | MET325 |
| F | MET414 |
| F | GLN441 |
| F | IMP601 |
| E | THR45 |
| E | GLN469 |
| F | HIS93 |
| F | THR252 |
| F | HIS253 |
| F | ASP274 |
| F | SER276 |
| F | PHE282 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue NAD G 602 |
| Chain | Residue |
| F | THR45 |
| F | GLN469 |
| G | HIS93 |
| G | THR252 |
| G | HIS253 |
| G | ASP274 |
| G | SER276 |
| G | PHE282 |
| G | ASN303 |
| G | ARG322 |
| G | GLY324 |
| G | MET325 |
| G | MET414 |
| G | GLN441 |
| G | IMP601 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | binding site for residue NAD H 602 |
| Chain | Residue |
| G | THR45 |
| G | GLN469 |
| H | HIS93 |
| H | THR252 |
| H | HIS253 |
| H | ASP274 |
| H | SER276 |
| H | PHE282 |
| H | ASN303 |
| H | ARG322 |
| H | GLY324 |
| H | MET325 |
| H | MET414 |
| H | GLN441 |
| H | IMP601 |
| site_id | AD1 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP B 601 and CYS B 331 |
| Chain | Residue |
| A | GLY501 |
| A | GLY502 |
| B | SER68 |
| B | MET70 |
| B | ARG322 |
| B | GLY328 |
| B | SER329 |
| B | ILE330 |
| B | ILE332 |
| B | THR333 |
| B | ASP364 |
| B | GLY365 |
| B | GLY387 |
| B | SER388 |
| B | TYR411 |
| B | GLY413 |
| B | MET414 |
| B | GLY415 |
| B | GLN441 |
| B | NAD602 |
| site_id | AD2 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP B 601 and CYS B 331 |
| Chain | Residue |
| A | GLY501 |
| A | GLY502 |
| B | SER68 |
| B | MET70 |
| B | ARG322 |
| B | GLY328 |
| B | SER329 |
| B | ILE330 |
| B | ILE332 |
| B | THR333 |
| B | ASP364 |
| B | GLY365 |
| B | GLY387 |
| B | SER388 |
| B | TYR411 |
| B | GLY413 |
| B | MET414 |
| B | GLY415 |
| B | GLN441 |
| B | NAD602 |
| site_id | AD3 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP C 601 and CYS C 331 |
| Chain | Residue |
| B | GLY501 |
| B | GLY502 |
| C | SER68 |
| C | MET70 |
| C | ARG322 |
| C | GLY328 |
| C | SER329 |
| C | ILE330 |
| C | ILE332 |
| C | THR333 |
| C | ASP364 |
| C | GLY365 |
| C | GLY387 |
| C | SER388 |
| C | TYR411 |
| C | GLY413 |
| C | MET414 |
| C | GLY415 |
| C | GLN441 |
| C | NAD602 |
| site_id | AD4 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP C 601 and CYS C 331 |
| Chain | Residue |
| B | GLY501 |
| B | GLY502 |
| C | SER68 |
| C | MET70 |
| C | ARG322 |
| C | GLY328 |
| C | SER329 |
| C | ILE330 |
| C | ILE332 |
| C | THR333 |
| C | ASP364 |
| C | GLY365 |
| C | GLY387 |
| C | SER388 |
| C | TYR411 |
| C | GLY413 |
| C | MET414 |
| C | GLY415 |
| C | GLN441 |
| C | NAD602 |
| site_id | AD5 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP D 601 and CYS D 331 |
| Chain | Residue |
| C | GLY501 |
| C | GLY502 |
| D | SER68 |
| D | MET70 |
| D | ARG322 |
| D | GLY328 |
| D | SER329 |
| D | ILE330 |
| D | ILE332 |
| D | THR333 |
| D | ASP364 |
| D | GLY365 |
| D | GLY387 |
| D | SER388 |
| D | TYR411 |
| D | GLY413 |
| D | MET414 |
| D | GLY415 |
| D | GLN441 |
| D | NAD602 |
| site_id | AD6 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP D 601 and CYS D 331 |
| Chain | Residue |
| C | GLY501 |
| C | GLY502 |
| D | SER68 |
| D | MET70 |
| D | ARG322 |
| D | GLY328 |
| D | SER329 |
| D | ILE330 |
| D | ILE332 |
| D | THR333 |
| D | ASP364 |
| D | GLY365 |
| D | GLY387 |
| D | SER388 |
| D | TYR411 |
| D | GLY413 |
| D | MET414 |
| D | GLY415 |
| D | GLN441 |
| D | NAD602 |
| site_id | AD7 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP E 601 and CYS E 331 |
| Chain | Residue |
| E | SER68 |
| E | MET70 |
| E | ARG322 |
| E | GLY328 |
| E | SER329 |
| E | ILE330 |
| E | ILE332 |
| E | THR333 |
| E | ASP364 |
| E | GLY365 |
| E | GLY387 |
| E | SER388 |
| E | TYR411 |
| E | GLY413 |
| E | MET414 |
| E | GLY415 |
| E | GLN441 |
| E | NAD602 |
| H | GLY501 |
| H | GLY502 |
| site_id | AD8 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP E 601 and CYS E 331 |
| Chain | Residue |
| E | SER68 |
| E | MET70 |
| E | ARG322 |
| E | GLY328 |
| E | SER329 |
| E | ILE330 |
| E | ILE332 |
| E | THR333 |
| E | ASP364 |
| E | GLY365 |
| E | GLY387 |
| E | SER388 |
| E | TYR411 |
| E | GLY413 |
| E | MET414 |
| E | GLY415 |
| E | GLN441 |
| E | NAD602 |
| H | GLY501 |
| H | GLY502 |
| site_id | AD9 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP F 601 and CYS F 331 |
| Chain | Residue |
| E | GLY501 |
| E | GLY502 |
| F | SER68 |
| F | MET70 |
| F | ARG322 |
| F | GLY328 |
| F | SER329 |
| F | ILE330 |
| F | ILE332 |
| F | THR333 |
| F | ASP364 |
| F | GLY365 |
| F | GLY387 |
| F | SER388 |
| F | TYR411 |
| F | GLY413 |
| F | MET414 |
| F | GLY415 |
| F | GLN441 |
| F | NAD602 |
| site_id | AE1 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP F 601 and CYS F 331 |
| Chain | Residue |
| E | GLY501 |
| E | GLY502 |
| F | SER68 |
| F | MET70 |
| F | ARG322 |
| F | GLY328 |
| F | SER329 |
| F | ILE330 |
| F | ILE332 |
| F | THR333 |
| F | ASP364 |
| F | GLY365 |
| F | GLY387 |
| F | SER388 |
| F | TYR411 |
| F | GLY413 |
| F | MET414 |
| F | GLY415 |
| F | GLN441 |
| F | NAD602 |
| site_id | AE2 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP G 601 and CYS G 331 |
| Chain | Residue |
| F | GLY501 |
| F | GLY502 |
| G | SER68 |
| G | MET70 |
| G | ARG322 |
| G | GLY328 |
| G | SER329 |
| G | ILE330 |
| G | ILE332 |
| G | THR333 |
| G | ASP364 |
| G | GLY365 |
| G | GLY387 |
| G | SER388 |
| G | TYR411 |
| G | GLY413 |
| G | MET414 |
| G | GLY415 |
| G | GLN441 |
| G | NAD602 |
| site_id | AE3 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP G 601 and CYS G 331 |
| Chain | Residue |
| F | GLY501 |
| F | GLY502 |
| G | SER68 |
| G | MET70 |
| G | ARG322 |
| G | GLY328 |
| G | SER329 |
| G | ILE330 |
| G | ILE332 |
| G | THR333 |
| G | ASP364 |
| G | GLY365 |
| G | GLY387 |
| G | SER388 |
| G | TYR411 |
| G | GLY413 |
| G | MET414 |
| G | GLY415 |
| G | GLN441 |
| G | NAD602 |
| site_id | AE4 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP H 601 and CYS H 331 |
| Chain | Residue |
| G | GLY501 |
| G | GLY502 |
| H | SER68 |
| H | MET70 |
| H | ARG322 |
| H | GLY328 |
| H | SER329 |
| H | ILE330 |
| H | ILE332 |
| H | THR333 |
| H | ASP364 |
| H | GLY365 |
| H | GLY387 |
| H | SER388 |
| H | TYR411 |
| H | GLY413 |
| H | MET414 |
| H | GLY415 |
| H | GLN441 |
| H | NAD602 |
| site_id | AE5 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide IMP H 601 and CYS H 331 |
| Chain | Residue |
| G | GLY501 |
| G | GLY502 |
| H | SER68 |
| H | MET70 |
| H | ARG322 |
| H | GLY328 |
| H | SER329 |
| H | ILE330 |
| H | ILE332 |
| H | THR333 |
| H | ASP364 |
| H | GLY365 |
| H | GLY387 |
| H | SER388 |
| H | TYR411 |
| H | GLY413 |
| H | MET414 |
| H | GLY415 |
| H | GLN441 |
| H | NAD602 |
Functional Information from PROSITE/UniProt
| site_id | PS00487 |
| Number of Residues | 13 |
| Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGsGSICiT |
| Chain | Residue | Details |
| A | LEU321-THR333 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Thioimidate intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10097070","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 88 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2002","submissionDatabase":"PDB data bank","title":"Crystal structure of human inosine monophosphate dehydrogenase type II complexed with the MPA/NAD analog C2-MAD.","authors":["Risal D.","Strickler M.D.","Goldstein B.M."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
