6U7P
HIV-1 wild type protease with GRL-03119A, with phenyl-boronic-acid as P2'-ligand and with a hexahydro-4H-furo-pyran as the P2-ligand
Summary for 6U7P
Entry DOI | 10.2210/pdb6u7p/pdb |
Related | 2IEN 4I8W 4I8Z 6C8X 6U7O |
Descriptor | Protease, {4-[{(2R,3S)-3-[({[(3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl]oxy}carbonyl)amino]-2-hydroxy-4-phenylbutyl}(2-methylpropyl)sulfamoyl]phenyl}boronic acid, SODIUM ION, ... (7 entities in total) |
Functional Keywords | aspartic acid protease, hiv-1 protease inhibitor of grl-03119a, boronic acid, viral protein |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22410.22 |
Authors | Wang, Y.-F.,Kneller, D.W.,Weber, I.T. (deposition date: 2019-09-03, release date: 2019-10-09, Last modification date: 2023-10-11) |
Primary citation | Ghosh, A.K.,Xia, Z.,Kovela, S.,Robinson, W.L.,Johnson, M.E.,Kneller, D.W.,Wang, Y.F.,Aoki, M.,Takamatsu, Y.,Weber, I.T.,Mitsuya, H. Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies. Chemmedchem, 14:1863-1872, 2019 Cited by PubMed: 31549492DOI: 10.1002/cmdc.201900508 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.13 Å) |
Structure validation
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