6U7P

HIV-1 wild type protease with GRL-03119A, with phenyl-boronic-acid as P2'-ligand and with a hexahydro-4H-furo-pyran as the P2-ligand

6U7P の概要

• エントリーDOI: 10.2210/pdb6u7p/pdb
• 関連するPDBエントリー: 2IEN 4I8W 4I8Z 6C8X 6U7O
• 分子名称: Protease, {4-[{(2R,3S)-3-[({[(3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl]oxy}carbonyl)amino]-2-hydroxy-4-phenylbutyl}(2-methylpropyl)sulfamoyl]phenyl}boronic acid, SODIUM ION, ... (7 entities in total)
• 機能のキーワード: aspartic acid protease, hiv-1 protease inhibitor of grl-03119a, boronic acid, viral protein
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22410.22

構造登録者

Wang, Y.-F.,Kneller, D.W.,Weber, I.T. (登録日: 2019-09-03, 公開日: 2019-10-09, 最終更新日: 2023-10-11)

• 主引用文献: Ghosh, A.K.,Xia, Z.,Kovela, S.,Robinson, W.L.,Johnson, M.E.,Kneller, D.W.,Wang, Y.F.,Aoki, M.,Takamatsu, Y.,Weber, I.T.,Mitsuya, H.; Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies.; Chemmedchem, 14:1863-1872, 2019; PubMed: 31549492; DOI: 10.1002/cmdc.201900508

実験手法

X-RAY DIFFRACTION (1.13 Å)