6U5L

Structure of human ULK4 in complex with an inhibitor

Summary for 6U5L

Entry DOI	10.2210/pdb6u5l/pdb
Descriptor	Serine/threonine-protein kinase ULK4, N~2~-(1H-benzimidazol-6-yl)-N~4~-(5-cyclobutyl-1H-pyrazol-3-yl)quinazoline-2,4-diamine, GLYCEROL, ... (5 entities in total)
Functional Keywords	kinase, pseudokinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33191.07
Authors	Khamrui, S.,Lazarus, M.B. (deposition date: 2019-08-28, release date: 2019-12-25, Last modification date: 2023-10-11)
Primary citation	Khamrui, S.,Ung, P.M.U.,Secor, C.,Schlessinger, A.,Lazarus, M.B. High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4. J.Am.Chem.Soc., 142:33-37, 2020 Cited by PubMed: 31841327 DOI: 10.1021/jacs.9b10458 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation