6U18

Directed evolution of a biosensor selective for the macrolide antibiotic clarithromycin

6U18 の概要

• エントリーDOI: 10.2210/pdb6u18/pdb
• 分子名称: Erythromycin resistance repressor protein, CLARITHROMYCIN, CITRATE ANION, ... (4 entities in total)
• 機能のキーワード: macrolide, biosensor, dna-binding, dna binding protein-antibiotic complex, dna binding protein/antibiotic
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44888.96

構造登録者

Li, Y.,Reed, M.,Wright, H.T.,Cropp, T.A.,Williams, G. (登録日: 2019-08-15, 公開日: 2020-08-19, 最終更新日: 2023-10-11)

• 主引用文献: Li, Y.,Reed, M.,Wright, H.T.,Cropp, T.A.,Williams, G.J.; Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics.; Acs Synth Biol, 2021; PubMed: 34546703; DOI: 10.1021/acssynbio.1c00151

実験手法

X-RAY DIFFRACTION (2 Å)