6TYP

KEAP1 Kelch domain in complex with Compound 2

Summary for 6TYP

Entry DOI	10.2210/pdb6typ/pdb
Descriptor	Kelch-like ECH-associated protein 1, FORMIC ACID, (3S)-3-[2-(benzenecarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-3-(1-ethyl-4-methyl-1H-benzotriazol-5-yl)propanoic acid, ... (4 entities in total)
Functional Keywords	keap1 kelch domain, peptide binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32582.42
Authors	Marcotte, D.J. (deposition date: 2019-08-09, release date: 2020-01-15, Last modification date: 2023-10-11)
Primary citation	Ma, B.,Lucas, B.,Capacci, A.,Lin, E.Y.,Jones, J.H.,Dechantsreiter, M.,Enyedy, I.,Marcotte, D.,Xiao, G.,Li, B.,Richter, K. Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators. Bioorg.Med.Chem.Lett., 30:126852-126852, 2020 Cited by PubMed: 31898999 DOI: 10.1016/j.bmcl.2019.126852 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation