6TYP

KEAP1 Kelch domain in complex with Compound 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue FMT A 801

Chain	Residue
A	TYR491
A	PRO492
A	GLU493
A	ARG494

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site_id	AC2
Number of Residues	13
Details	binding site for residue PKG A 802

Chain	Residue
A	SER508
A	TYR525
A	GLN530
A	SER555
A	ALA556
A	PHE577
A	SER602
A	GLY603
A	TYR334
A	GLY364
A	ARG415
A	PHE478
A	ARG483

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Sensor for electrophilic agents => ECO:0000250|UniProtKB:Q9Z2X8

Chain	Residue	Details
A	CYS434

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: S-cGMP-cysteine => ECO:0000250|UniProtKB:Q9Z2X8

Chain	Residue	Details
A	CYS434

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