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6TW9

HumRadA22F in complex with CAM833

Summary for 6TW9
Entry DOI10.2210/pdb6tw9/pdb
DescriptorDNA repair and recombination protein RadA, ~{N}-[2-[(2~{S},4~{R})-2-[[(1~{S})-1-(2-chloranyl-4-methoxy-phenyl)ethyl]carbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-2-oxidanylidene-ethyl]-6-fluoranyl-quinoline-2-carboxamide, CALCIUM ION, ... (5 entities in total)
Functional Keywordsrad51, recombinase, dna repair, dna binding protein
Biological sourcePyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Total number of polymer chains1
Total formula weight26060.03
Authors
Fischer, G.,Marsh, M.E.,Scott, D.E.,Coyne, A.G.,Skidmore, J.,Abell, C.,Hyvonen, M. (deposition date: 2020-01-12, release date: 2021-01-27, Last modification date: 2024-01-24)
Primary citationScott, D.E.,Francis-Newton, N.J.,Marsh, M.E.,Coyne, A.G.,Fischer, G.,Moschetti, T.,Bayly, A.R.,Sharpe, T.D.,Haas, K.T.,Barber, L.,Valenzano, C.R.,Srinivasan, R.,Huggins, D.J.,Lee, M.,Emery, A.,Hardwick, B.,Ehebauer, M.,Dagostin, C.,Esposito, A.,Pellegrini, L.,Perrior, T.,McKenzie, G.,Blundell, T.L.,Hyvonen, M.,Skidmore, J.,Venkitaraman, A.R.,Abell, C.
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Cell Chem Biol, 28:835-, 2021
Cited by
PubMed: 33662256
DOI: 10.1016/j.chembiol.2021.02.006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.52 Å)
Structure validation

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