6TU9
The ROR1 Pseudokinase Domain Bound To Ponatinib
Summary for 6TU9
Entry DOI | 10.2210/pdb6tu9/pdb |
Descriptor | Inactive tyrosine-protein kinase transmembrane receptor ROR1, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide (3 entities in total) |
Functional Keywords | receptor transmembrane kinase pseudokinase small-molecule inhibitor, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 71962.55 |
Authors | Mathea, S.,Preuss, F.,Chatterjee, D.,Niininen, W.,Ungureanu, D.,Shin, D.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S. (deposition date: 2020-01-04, release date: 2020-01-22, Last modification date: 2024-01-24) |
Primary citation | Sheetz, J.B.,Mathea, S.,Karvonen, H.,Malhotra, K.,Chatterjee, D.,Niininen, W.,Perttila, R.,Preuss, F.,Suresh, K.,Stayrook, S.E.,Tsutsui, Y.,Radhakrishnan, R.,Ungureanu, D.,Knapp, S.,Lemmon, M.A. Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases. Mol.Cell, 79:390-405.e7, 2020 Cited by PubMed: 32619402DOI: 10.1016/j.molcel.2020.06.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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