6TU9
The ROR1 Pseudokinase Domain Bound To Ponatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | polymer | 306 | 35448.7 | 2 | UniProt (Q01973) Pfam (PF07714) | Homo sapiens (Human) | Neurotrophic tyrosine kinase,receptor-related 1 |
| 2 | C, D (A, B) | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 2 | Chemie (0LI) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A, B: 453 - 752 (UniProt: Q01973)
| PDB | External Database | Details |
|---|---|---|
| Met 518 | Thr 518 | conflict |
| His 753 | - | expression tag |
| His 754 | - | expression tag |
| His 755 | - | expression tag |
| His 756 | - | expression tag |
| His 757 | - | expression tag |
| His 758 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70897.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1065.1 | |
| All* | Total formula weight | 71962.5 |
