6TU9

The ROR1 Pseudokinase Domain Bound To Ponatinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Inactive tyrosine-protein kinase transmembrane receptor ROR1	polymer	306	35448.7	2	UniProt (Q01973) Pfam (PF07714) In PDB	Homo sapiens (Human)	Neurotrophic tyrosine kinase,receptor-related 1
2	A, B	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide	non-polymer		532.6	2	Chemie (0LI)
3		water	water		18.0	94	Chemie (HOH)

Sequence modifications

A, B: 453 - 752 (UniProt: Q01973)

PDB	External Database	Details
Met 518	Thr 518	conflict
His 753	-	expression tag
His 754	-	expression tag
His 755	-	expression tag
His 756	-	expression tag
His 757	-	expression tag
His 758	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70897.4
Non-Polymers*	Number of molecules	2
	Total formula weight	1065.1
All*	Total formula weight	71962.5

*Water molecules are not included.