6TTT

Crystal structure of the human METTL3-METTL14 complex bound to Compound 2 (ASI_M3M_140)

Summary for 6TTT

• Entry DOI: 10.2210/pdb6ttt/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-~{N}-methyl-3,4-bis(oxidanyl)oxolane-2-carboxamide, ... (5 entities in total)
• Functional Keywords: compound, complex, mettl3, mettl14, epitranscriptomic, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 117145.64

Authors

Bedi, R.K.,Huang, D.,Sledz, P.,Caflisch, A. (deposition date: 2019-12-30, release date: 2020-03-04, Last modification date: 2024-01-24)

• Primary citation: Bedi, R.K.,Huang, D.,Eberle, S.A.,Wiedmer, L.,Sledz, P.,Caflisch, A.; Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.; Chemmedchem, 15:744-748, 2020; PubMed: 32159918; DOI: 10.1002/cmdc.202000011

Experimental method

X-RAY DIFFRACTION (2.3 Å)