6TTT
Crystal structure of the human METTL3-METTL14 complex bound to Compound 2 (ASI_M3M_140)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N6-adenosine-methyltransferase catalytic subunit | polymer | 580 | 64562.9 | 1 | UniProt (Q86U44) Pfam (PF05063) | Homo sapiens (Human) | Methyltransferase-like protein 3,hMETTL3,N6-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
| 2 | B (B) | N6-adenosine-methyltransferase non-catalytic subunit | polymer | 456 | 52229.4 | 1 | UniProt (Q9HCE5) Pfam (PF05063) | Homo sapiens (Human) | Methyltransferase-like protein 14,hMETTL14 |
| 3 | C (A) | (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-~{N}-methyl-3,4-bis(oxidanyl)oxolane-2-carboxamide | non-polymer | 294.3 | 1 | Chemie (NWQ) | |||
| 4 | D (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 116792.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 353.3 | |
| All* | Total formula weight | 117145.6 |
