6TQL

Cryo-EM of elastase-treated human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament

6TQL の概要

• エントリーDOI: 10.2210/pdb6tql/pdb
• 関連するPDBエントリー: 3NK4 4WRN 6TQK
• EMDBエントリー: 10553 10554
• 分子名称: Uromodulin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: zp module, zp domain, zp-n domain, zp-c domain, interdomain linker, egf domain, extracellular matrix, glycoprotein, n-glycan, structural protein, protein filament, protein polymerization
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 104332.14

構造登録者

Stsiapanava, A.,Xu, C.,Carroni, M.,Wu, B.,Jovine, L. (登録日: 2019-12-16, 公開日: 2020-11-04, 最終更新日: 2021-03-03)

• 主引用文献: Stsiapanava, A.,Xu, C.,Brunati, M.,Zamora-Caballero, S.,Schaeffer, C.,Bokhove, M.,Han, L.,Hebert, H.,Carroni, M.,Yasumasu, S.,Rampoldi, L.,Wu, B.,Jovine, L.; Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.; Embo J., 39:e106807-e106807, 2020; PubMed: 33196145; DOI: 10.15252/embj.2020106807

実験手法

ELECTRON MICROSCOPY (3.96 Å)