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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6TQL

Cryo-EM of elastase-treated human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament

Functional Information from PROSITE/UniProt
site_idPS00682
Number of Residues41
DetailsZP_1 ZP domain signature. VgtmldggDlsrFaLlMtnCYaTPss..NaTdplkyfIIqdr.C
ChainResidueDetails
AVAL487-CYS527
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues62
DetailsDomain: {"description":"EGF-like 4","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues190
DetailsRegion: {"description":"ZP-N","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues23
DetailsRegion: {"description":"Flexible ZP-N/ZP-C linker; important for secretion and polymerization into filaments","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues22
DetailsRegion: {"description":"Internal hydrophobic patch (IHP)","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine; alternate","evidences":[{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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