6TN8

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound BI-9564

Summary for 6TN8

• Entry DOI: 10.2210/pdb6tn8/pdb
• Descriptor: Activin receptor type I, 1,4-DIETHYLENE DIOXIDE, 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, ... (6 entities in total)
• Functional Keywords: kinase, bmp, inhibitor, signalling, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35621.80

Authors

Williams, E.P.,Chen, Z.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2019-12-06, release date: 2019-12-18, Last modification date: 2024-01-24)

• Primary citation: Williams, E.P.,Chen, Z.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.; Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound BI-9564; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.63 Å)