6TN8
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound BI-9564
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Activin receptor type I | polymer | 301 | 34537.6 | 1 | UniProt (Q04771) Pfam (PF00069) | Homo sapiens (Human) | |
| 2 | B, C, D, E (A) | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 4 | Chemie (DIO) | |||
| 3 | F (A) | 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one | non-polymer | 353.4 | 1 | Chemie (5U6) | |||
| 4 | G, H (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | I, J, K (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | L (A) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| Asp 207 | Gln 207 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34537.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1084.2 | |
| All* | Total formula weight | 35621.8 |
