6TLQ

ROR(gamma)t ligand binding domain in complex with cholesterol and allosteric ligand Glenmark

6TLQ の概要

• エントリーDOI: 10.2210/pdb6tlq/pdb
• 分子名称: Nuclear receptor ROR-gamma, CHOLESTEROL, 4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic acid, ... (5 entities in total)
• 機能のキーワード: nuclear receptor, allosteric, inverse agonist, inhibitor, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31608.39

構造登録者

de Vries, R.M.J.M.,Meijer, F.A.,Brunsveld, L. (登録日: 2019-12-03, 公開日: 2020-12-16, 最終更新日: 2024-01-24)

• 主引用文献: de Vries, R.M.J.M.,Meijer, F.A.,Doveston, R.G.,Leijten-van de Gevel, I.A.,Brunsveld, L.; Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33536342; DOI: 10.1073/pnas.2021287118

実験手法

X-RAY DIFFRACTION (1.761 Å)