6TKV

Crystal structure of the human FUT8 in complex with GDP and a biantennary complex N-glycan

Summary for 6TKV

• Entry DOI: 10.2210/pdb6tkv/pdb
• Descriptor: Alpha-(1,6)-fucosyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: glycosyltransferase, sugar nucleotide, acceptor substrate, catalysis, sugar binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 111371.82

Authors

Garcia-Garcia, A.,Ceballos-Laita, L.,Serna, L.,Artschwager, R.,Reichardt, N.C.,Corzana, F.,Hurtado-Guerrero, R. (deposition date: 2019-11-29, release date: 2020-01-29, Last modification date: 2024-01-24)

• Primary citation: Garcia-Garcia, A.,Ceballos-Laita, L.,Serna, S.,Artschwager, R.,Reichardt, N.C.,Corzana, F.,Hurtado-Guerrero, R.; Structural basis for substrate specificity and catalysis of alpha 1,6-fucosyltransferase.; Nat Commun, 11:973-973, 2020; PubMed: 32080177; DOI: 10.1038/s41467-020-14794-z

Experimental method

X-RAY DIFFRACTION (1.95 Å)