6TKV
Crystal structure of the human FUT8 in complex with GDP and a biantennary complex N-glycan
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Alpha-(1,6)-fucosyltransferase | polymer | 468 | 53966.0 | 1 | UniProt (Q9BYC5) Pfam (PF19745) Pfam (PF14604) | Homo sapiens (Human) | Alpha1-6FucT,Fucosyltransferase 8,GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase,GDP-fucose--glycoprotein fucosyltransferase,Glycoprotein 6-alpha-L-fucosyltransferase |
| 2 | B (B) | Alpha-(1,6)-fucosyltransferase | polymer | 453 | 52319.4 | 1 | UniProt (Q9BYC5) Pfam (PF19745) Pfam (PF14604) | Homo sapiens (Human) | Alpha1-6FucT,Fucosyltransferase 8,GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase,GDP-fucose--glycoprotein fucosyltransferase,Glycoprotein 6-alpha-L-fucosyltransferase |
| 3 | C, D (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1317.2 | 2 | In PDB GlyTouCan (G39213VZ) | |||
| 4 | E, J (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 5 | F, G, H, I, K... (A, B) | GLYCEROL | non-polymer | 92.1 | 17 | Chemie (GOL) PubChem (753) | |||
| 6 | X, Y (A, B) | water | water | 18.0 | 504 | Chemie (HOH) |
Sequence modifications
B: 108 - 575 (UniProt: Q9BYC5)
| PDB | External Database | Details |
|---|---|---|
| - | Asn 430 | deletion |
| - | Ser 431 | deletion |
| - | Ile 432 | deletion |
| - | Ser 433 | deletion |
| - | Trp 434 | deletion |
| - | Ser 435 | deletion |
| - | Ala 436 | deletion |
| - | Gly 437 | deletion |
| - | Leu 438 | deletion |
| - | His 439 | deletion |
| - | Asn 440 | deletion |
| - | Arg 441 | deletion |
| - | Tyr 442 | deletion |
| - | Thr 443 | deletion |
| - | Glu 444 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 106285.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2634.4 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2452.0 | |
| All* | Total formula weight | 111371.8 |
