6TKV

Crystal structure of the human FUT8 in complex with GDP and a biantennary complex N-glycan

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Alpha-(1,6)-fucosyltransferase	polymer	468	53966.0	1	UniProt (Q9BYC5) Pfam (PF19745) Pfam (PF14604) In PDB	Homo sapiens (Human)	Alpha1-6FucT,Fucosyltransferase 8,GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase,GDP-fucose--glycoprotein fucosyltransferase,Glycoprotein 6-alpha-L-fucosyltransferase
2	B	Alpha-(1,6)-fucosyltransferase	polymer	453	52319.4	1	UniProt (Q9BYC5) Pfam (PF19745) Pfam (PF14604) In PDB	Homo sapiens (Human)	Alpha1-6FucT,Fucosyltransferase 8,GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase,GDP-fucose--glycoprotein fucosyltransferase,Glycoprotein 6-alpha-L-fucosyltransferase
3	C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1317.2	2	In PDB GlyTouCan (G39213VZ)
4	A, B	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
5	A, B	GLYCEROL	non-polymer		92.1	17	Chemie (GOL)
6		water	water		18.0	504	Chemie (HOH)

Sequence modifications

B: 108 - 575 (UniProt: Q9BYC5)

PDB	External Database	Details
-	Asn 430	deletion
-	Ser 431	deletion
-	Ile 432	deletion
-	Ser 433	deletion
-	Trp 434	deletion
-	Ser 435	deletion
-	Ala 436	deletion
-	Gly 437	deletion
-	Leu 438	deletion
-	His 439	deletion
-	Asn 440	deletion
-	Arg 441	deletion
-	Tyr 442	deletion
-	Thr 443	deletion
-	Glu 444	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	106285.4
Branched	Number of molecules	2
	Total formula weight	2634.4
Non-Polymers*	Number of molecules	19
	Total formula weight	2452.0
All*	Total formula weight	111371.8

*Water molecules are not included.