6TJ9

Escherichia coli transketolase in complex with cofactor analog 2'-methoxythiamine and substrate xylulose 5-phosphate

6TJ9 の概要

• エントリーDOI: 10.2210/pdb6tj9/pdb
• 分子名称: Transketolase 1, 5-O-phosphono-D-xylulose, 2-[3-[(4-azanyl-2-methoxy-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, ... (7 entities in total)
• 機能のキーワード: thiamin diphosphate, enzyme catalysis, pentose phosphate pathway, transferase
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 149325.77

構造登録者

Rabe von Pappenheim, F.,Tittmann, K. (登録日: 2019-11-25, 公開日: 2020-07-08, 最終更新日: 2024-01-24)

• 主引用文献: Rabe von Pappenheim, F.,Aldeghi, M.,Shome, B.,Begley, T.,de Groot, B.L.,Tittmann, K.; Structural basis for antibiotic action of the B 1 antivitamin 2'-methoxy-thiamine.; Nat.Chem.Biol., 16:1237-1245, 2020; PubMed: 32839604; DOI: 10.1038/s41589-020-0628-4

実験手法

X-RAY DIFFRACTION (0.95 Å)