6THP

Neprilysin in complex with the inhibitor (R)-4-(1-carboxy-3-(3'-chlorobiphenyl-4-yl)propan-2-ylamino)-4-oxobutanoic acid

Summary for 6THP

• Entry DOI: 10.2210/pdb6thp/pdb
• Descriptor: Neprilysin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 161731.16

Authors

Schiering, N.,Wiesmann, C. (deposition date: 2019-11-21, release date: 2020-02-12, Last modification date: 2024-01-24)

• Primary citation: Kawanami, T.,Karki, R.G.,Cody, E.,Liu, Q.,Liang, G.,Ksander, G.M.,Rigel, D.F.,Schiering, N.,Gong, Y.,Coppola, G.M.,Iwaki, Y.,Sun, R.,Neubert, A.,Fan, L.,Ingles, S.,D'Arcy, A.,Villard, F.,Ramage, P.,Jeng, A.Y.,Leung-Chu, J.,Liu, J.,Beil, M.,Fu, F.,Chen, W.,Cumin, F.,Wiesmann, C.,Mogi, M.; Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.; Acs Med.Chem.Lett., 11:188-194, 2020; PubMed: 32071687; DOI: 10.1021/acsmedchemlett.9b00578

Experimental method

X-RAY DIFFRACTION (2.54 Å)