6TGU
Crystal structure of human protein kinase CK2alpha'(CSNK2A2 gene product) in complex with the 2-aminothiazole-type inhibitor Cl-OH-3
Summary for 6TGU
| Entry DOI | 10.2210/pdb6tgu/pdb |
| Related | 6TE2 6TEW |
| Descriptor | Casein kinase II subunit alpha', 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]-2-oxidanyl-benzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
| Functional Keywords | protein kinase ck2, casein kinase 2, atp-competitive inhibitor, 2-aminothiazole derivative, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 43661.13 |
| Authors | Niefind, K.,Lindenblatt, D.,Jose, J.,Applegate, V.M.,Nickelsen, A. (deposition date: 2019-11-18, release date: 2020-07-08, Last modification date: 2020-08-05) |
| Primary citation | Lindenblatt, D.,Nickelsen, A.,Applegate, V.M.,Jose, J.,Niefind, K. Structural and Mechanistic Basis of the Inhibitory Potency of Selected 2-Aminothiazole Compounds on Protein Kinase CK2. J.Med.Chem., 63:7766-7772, 2020 Cited by PubMed: 32589844DOI: 10.1021/acs.jmedchem.0c00587 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (0.833 Å) |
Structure validation
Download full validation report
