6TD3

Structure of DDB1 bound to CR8-engaged CDK12-cyclinK

6TD3 の概要

• エントリーDOI: 10.2210/pdb6td3/pdb
• 分子名称: DNA damage-binding protein 1, Cyclin-dependent kinase 12, Cyclin-K, ... (4 entities in total)
• 機能のキーワード: ubiquitin ligase kinase cyclin cdk, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 497852.31

構造登録者

Bunker, R.D.,Petzold, G.,Kozicka, Z.,Thoma, N.H. (登録日: 2019-11-07, 公開日: 2020-06-17, 最終更新日: 2024-01-24)

• 主引用文献: Slabicki, M.,Kozicka, Z.,Petzold, G.,Li, Y.D.,Manojkumar, M.,Bunker, R.D.,Donovan, K.A.,Sievers, Q.L.,Koeppel, J.,Suchyta, D.,Sperling, A.S.,Fink, E.C.,Gasser, J.A.,Wang, L.R.,Corsello, S.M.,Sellar, R.S.,Jan, M.,Gillingham, D.,Scholl, C.,Frohling, S.,Golub, T.R.,Fischer, E.S.,Thoma, N.H.,Ebert, B.L.; The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.; Nature, 585:293-297, 2020; PubMed: 32494016; DOI: 10.1038/s41586-020-2374-x

実験手法

X-RAY DIFFRACTION (3.46 Å)