6TBX

Trypanosoma brucei PTR1 (TbPTR1) in complex with a tricyclic-based inhibitor

Summary for 6TBX

Entry DOI	10.2210/pdb6tbx/pdb
Descriptor	Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-bis(azanyl)-9~{H}-pyrimido[4,5-b]indol-6-ol, ... (7 entities in total)
Functional Keywords	trypanosoma brucei, pteridine reductase, tbptr1, tricyclic based inhibitor, oxidoreductase
Biological source	Trypanosoma brucei brucei More
Total number of polymer chains	4
Total formula weight	126739.81
Authors	Landi, G.,Tassone, G.,Pozzi, C.,Mangani, S. (deposition date: 2019-11-04, release date: 2020-06-03, Last modification date: 2024-01-24)
Primary citation	Landi, G.,Linciano, P.,Tassone, G.,Costi, M.P.,Mangani, S.,Pozzi, C. High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor. Acta Crystallogr D Struct Biol, 76:558-564, 2020 Cited by PubMed: 32496217 DOI: 10.1107/S2059798320004891 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation