6TBX
Trypanosoma brucei PTR1 (TbPTR1) in complex with a tricyclic-based inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, D | Pteridine reductase | polymer | 288 | 30669.8 | 3 | UniProt (O76290) Pfam (PF13561) In PDB | Trypanosoma brucei brucei | |
2 | C | Pteridine reductase | polymer | 288 | 30685.8 | 1 | UniProt (O76290) Pfam (PF13561) In PDB | Trypanosoma brucei brucei | |
3 | A, B, C, D | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
4 | A, B, C, D | 2,4-bis(azanyl)-9~{H}-pyrimido[4,5-b]indol-6-ol | non-polymer | 215.2 | 4 | Chemie (N0Z) | |||
5 | B, D | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
6 | C | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
7 | water | water | 18.0 | 740 | Chemie (HOH) |
Sequence modifications
A, B, D: 1 - 268 (UniProt: O76290)
C: 1 - 268 (UniProt: O76290)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 122695.2 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 4044.6 | |
All* | Total formula weight | 126739.8 |