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6T9T

Matriptase in complex with the synthetic inhibitor (S)-3-(3-(4-(3-(tert-butyl)ureido)piperidin-1-yl)-2-((3'-fluoro-4'-(hydroxymethyl)-[1,1'-biphenyl])-3-sulfonamido)-3-oxopropyl)benzimidamide (MI-1904)

Summary for 6T9T
Entry DOI10.2210/pdb6t9t/pdb
DescriptorSuppressor of tumorigenicity 14 protein, CHLORIDE ION, 1-~{tert}-butyl-3-[1-[(2~{S})-3-(3-carbamimidoylphenyl)-2-[[3-[3-fluoranyl-4-(hydroxymethyl)phenyl]phenyl]sulfonylamino ]propanoyl]piperidin-4-yl]urea, ... (4 entities in total)
Functional Keywordsmatriptase, complex, ligand-binding, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight27135.92
Authors
Mueller, J.M.,Merkl, S.,Keils, A.,Pilgram, O.,Steinmetzer, T. (deposition date: 2019-10-28, release date: 2020-11-18, Last modification date: 2024-01-24)
Primary citationPilgram, O.,Keils, A.,Benary, G.E.,Muller, J.,Merkl, S.,Ngaha, S.,Huber, S.,Chevillard, F.,Harbig, A.,Magdolen, V.,Heine, A.,Bottcher-Friebertshauser, E.,Steinmetzer, T.
Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors
Eur.J.Med.Chem., :114437-, 2022
Cited by
DOI: 10.1016/j.ejmech.2022.114437
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.69 Å)
Structure validation

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