6T9T

Matriptase in complex with the synthetic inhibitor (S)-3-(3-(4-(3-(tert-butyl)ureido)piperidin-1-yl)-2-((3'-fluoro-4'-(hydroxymethyl)-[1,1'-biphenyl])-3-sulfonamido)-3-oxopropyl)benzimidamide (MI-1904)

Summary for 6T9T

Entry DOI	10.2210/pdb6t9t/pdb
Descriptor	Suppressor of tumorigenicity 14 protein, CHLORIDE ION, 1-~{tert}-butyl-3-[1-[(2~{S})-3-(3-carbamimidoylphenyl)-2-[[3-[3-fluoranyl-4-(hydroxymethyl)phenyl]phenyl]sulfonylamino ]propanoyl]piperidin-4-yl]urea, ... (4 entities in total)
Functional Keywords	matriptase, complex, ligand-binding, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	27135.92
Authors	Mueller, J.M.,Merkl, S.,Keils, A.,Pilgram, O.,Steinmetzer, T. (deposition date: 2019-10-28, release date: 2020-11-18, Last modification date: 2024-11-13)
Primary citation	Pilgram, O.,Keils, A.,Benary, G.E.,Muller, J.,Merkl, S.,Ngaha, S.,Huber, S.,Chevillard, F.,Harbig, A.,Magdolen, V.,Heine, A.,Bottcher-Friebertshauser, E.,Steinmetzer, T. Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors Eur.J.Med.Chem., :114437-, 2022 Cited by DOI: 10.1016/j.ejmech.2022.114437 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation