6T9T
Matriptase in complex with the synthetic inhibitor (S)-3-(3-(4-(3-(tert-butyl)ureido)piperidin-1-yl)-2-((3'-fluoro-4'-(hydroxymethyl)-[1,1'-biphenyl])-3-sulfonamido)-3-oxopropyl)benzimidamide (MI-1904)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Suppressor of tumorigenicity 14 protein | polymer | 241 | 26447.7 | 1 | UniProt (Q9Y5Y6) Pfam (PF00089) In PDB | Homo sapiens (Human) | Matriptase,Membrane-type serine protease 1,MT-SP1,Prostamin,Serine protease 14,Serine protease TADG-15,Tumor-associated differentially-expressed gene 15 protein |
| 2 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | A | 1-~{tert}-butyl-3-[1-[(2~{S})-3-(3-carbamimidoylphenyl)-2-[[3-[3-fluoranyl-4-(hydroxymethyl)phenyl]phenyl]sulfonylamino ]propanoyl]piperidin-4-yl]urea | non-polymer | 652.8 | 1 | Chemie (MXH) | |||
| 4 | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A: 16 - 244 (UniProt: Q9Y5Y6)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | Cys 731 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26447.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 688.2 | |
| All* | Total formula weight | 27135.9 |
