6T6P

Crystal structure of Klebsiella pneumoniae FabG2(NADH-dependent) at 1.57 A resolution

Summary for 6T6P

• Entry DOI: 10.2210/pdb6t6p/pdb
• Descriptor: 3-oxoacyl-[acyl-carrier protein] reductase, PHOSPHATE ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: fatty acid biosynthesis, fabg, (3-oxoacyl-(acyl-carrier-protein) reductase), nadh, nadph, complex, fas-ii, biosynthetic protein
• Biological source: Klebsiella pneumoniae 30684/NJST258_2
• Total number of polymer chains: 4
• Total formula weight: 104887.18

Authors

Vella, P.,Schnell, R.,Lindqvist, Y.,Schneider, G. (deposition date: 2019-10-18, release date: 2020-11-18, Last modification date: 2024-01-24)

• Primary citation: Vella, P.,Rudraraju, R.S.,Lundback, T.,Axelsson, H.,Almqvist, H.,Vallin, M.,Schneider, G.,Schnell, R.; A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.; Bioorg.Med.Chem., 30:115898-115898, 2021; PubMed: 33388594; DOI: 10.1016/j.bmc.2020.115898

Experimental method

X-RAY DIFFRACTION (1.57 Å)