6T6P
Crystal structure of Klebsiella pneumoniae FabG2(NADH-dependent) at 1.57 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0032787 | biological_process | monocarboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0032787 | biological_process | monocarboxylic acid metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0032787 | biological_process | monocarboxylic acid metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0032787 | biological_process | monocarboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 301 |
| Chain | Residue |
| A | HIS98 |
| A | LYS99 |
| C | ARG128 |
| C | LYS172 |
| C | LYS173 |
| C | HOH517 |
| D | GOL305 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 302 |
| Chain | Residue |
| A | ALA78 |
| A | GLY80 |
| D | ARG49 |
| A | ARG31 |
| A | GLU77 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | ARG37 |
| A | CYS60 |
| A | ASN61 |
| A | ILE62 |
| A | HOH451 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | LYS164 |
| A | ARG168 |
| A | GLY233 |
| A | HOH426 |
| B | LEU144 |
| B | HOH434 |
| C | GLY241 |
| C | VAL243 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | ALA14 |
| A | HIS40 |
| A | ALA43 |
| A | SER47 |
| A | HOH499 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | ASN237 |
| A | MET242 |
| A | VAL243 |
| A | LEU244 |
| A | HOH402 |
| A | HOH405 |
| A | HOH408 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | LYS65 |
| A | HOH435 |
| A | HOH443 |
| B | HIS98 |
| B | LYS99 |
| B | LEU100 |
| B | THR101 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 308 |
| Chain | Residue |
| A | HIS98 |
| A | LYS99 |
| A | LEU100 |
| A | THR101 |
| A | HOH407 |
| B | LYS65 |
| B | ILE125 |
| B | HOH449 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 B 301 |
| Chain | Residue |
| B | ARG31 |
| B | GLU77 |
| B | ALA78 |
| C | ARG49 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | ALA14 |
| B | HIS40 |
| B | ALA43 |
| B | SER47 |
| B | HOH431 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 303 |
| Chain | Residue |
| B | ALA141 |
| B | TRP143 |
| B | ASN237 |
| B | MET242 |
| B | VAL243 |
| B | LEU244 |
| B | HOH404 |
| B | HOH456 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 304 |
| Chain | Residue |
| A | LEU144 |
| A | HOH437 |
| B | LYS164 |
| B | ARG168 |
| B | GLY233 |
| B | HOH424 |
| B | HOH527 |
| D | GLY241 |
| D | VAL243 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 305 |
| Chain | Residue |
| A | ARG128 |
| B | HIS98 |
| B | LYS99 |
| C | PO4301 |
| D | ARG128 |
| D | LYS172 |
| D | LYS173 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 C 301 |
| Chain | Residue |
| A | ARG128 |
| A | LYS172 |
| A | LYS173 |
| B | GOL305 |
| C | HIS98 |
| C | LYS99 |
| C | HOH405 |
| C | HOH466 |
| D | ARG128 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 302 |
| Chain | Residue |
| C | ALA14 |
| C | HIS40 |
| C | ALA43 |
| C | SER47 |
| C | HOH493 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 303 |
| Chain | Residue |
| A | GLY241 |
| A | VAL243 |
| C | LYS164 |
| C | ARG168 |
| C | GLY233 |
| C | HOH429 |
| C | HOH442 |
| C | HOH545 |
| D | LEU144 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 304 |
| Chain | Residue |
| C | ALA141 |
| C | ASN237 |
| C | MET242 |
| C | VAL243 |
| C | LEU244 |
| C | HOH412 |
| C | HOH413 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 305 |
| Chain | Residue |
| C | ARG37 |
| C | CYS60 |
| C | ASN61 |
| C | ILE62 |
| C | HOH404 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 306 |
| Chain | Residue |
| C | HIS98 |
| C | LYS99 |
| C | LEU100 |
| C | HOH425 |
| D | LYS65 |
| D | GLN121 |
| D | ILE125 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 301 |
| Chain | Residue |
| D | ALA14 |
| D | HIS40 |
| D | ALA43 |
| D | SER47 |
| D | HOH424 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 302 |
| Chain | Residue |
| D | ALA141 |
| D | TRP143 |
| D | ASN237 |
| D | MET242 |
| D | VAL243 |
| D | LEU244 |
| D | HOH401 |
| D | HOH408 |
| site_id | AE4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 303 |
| Chain | Residue |
| B | GLY241 |
| B | VAL243 |
| C | LEU144 |
| D | LYS164 |
| D | ARG168 |
| D | GLY233 |
| D | HOH431 |
| D | HOH455 |
| D | HOH530 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 304 |
| Chain | Residue |
| D | SER59 |
| D | GLN67 |
| D | ALA70 |
| D | GLN74 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 305 |
| Chain | Residue |
| A | PO4301 |
| B | ARG128 |
| B | LYS172 |
| B | LYS173 |
| C | ARG128 |
| D | HIS98 |
| D | LYS99 |
| D | HOH454 |
| D | HOH537 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 306 |
| Chain | Residue |
| C | LYS65 |
| C | HOH452 |
| D | HIS98 |
| D | LYS99 |
| D | LEU100 |
| D | THR101 |
| D | HOH533 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. AsaswlgnvgQtnYSASKAGVvGMTkTAC |
| Chain | Residue | Details |
| A | ALA139-CYS167 |
