6T5U
KRasG12C ligand complex
Summary for 6T5U
Entry DOI | 10.2210/pdb6t5u/pdb |
Descriptor | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | gtpase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 40047.88 |
Authors | Phillips, C. (deposition date: 2019-10-17, release date: 2020-02-19, Last modification date: 2024-05-01) |
Primary citation | Kettle, J.G.,Bagal, S.K.,Bickerton, S.,Bodnarchuk, M.S.,Breed, J.,Carbajo, R.J.,Cassar, D.J.,Chakraborty, A.,Cosulich, S.,Cumming, I.,Davies, M.,Eatherton, A.,Evans, L.,Feron, L.,Fillery, S.,Gleave, E.S.,Goldberg, F.W.,Harlfinger, S.,Hanson, L.,Howard, M.,Howells, R.,Jackson, A.,Kemmitt, P.,Kingston, J.K.,Lamont, S.,Lewis, H.J.,Li, S.,Liu, L.,Ogg, D.,Phillips, C.,Polanski, R.,Robb, G.,Robinson, D.,Ross, S.,Smith, J.M.,Tonge, M.,Whiteley, R.,Yang, J.,Zhang, L.,Zhao, X. Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C. J.Med.Chem., 63:4468-4483, 2020 Cited by PubMed: 32023060DOI: 10.1021/acs.jmedchem.9b01720 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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