6T5U
KRasG12C ligand complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b | polymer | 168 | 19094.5 | 2 | UniProt (A0A024RAV5) Pfam (PF00071) UniProt (by SIFTS) (A0A1S2ZE25) UniProt (by SIFTS) (P01116) | Homo sapiens (Human) | |
| 2 | C, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, G (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 4 | E, H (A, B) | 1-[(7R)-16-chloro-15-(5-methyl-1H-indazol-4-yl)-9-oxa-2,5,12-triazatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),11,13,15,17-pentaen-5-yl]prop-2-en-1-one | non-polymer | 461.9 | 2 | Chemie (MKW) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 166 (UniProt: A0A024RAV5)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | conflict |
| Ser 51 | Cys 51 | conflict |
| Leu 80 | Cys 80 | conflict |
| Ser 118 | Cys 118 | conflict |
| Lys 167 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38189.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1858.9 | |
| All* | Total formula weight | 40047.9 |
