6T4P
Human Carbonic anhydrase II bound by napthalene-1-sulfonamide
Summary for 6T4P
Entry DOI | 10.2210/pdb6t4p/pdb |
Related | 6T4N 6T4O |
Descriptor | carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (7 entities in total) |
Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29936.21 |
Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2019-10-14, release date: 2020-10-14, Last modification date: 2024-01-24) |
Primary citation | Dudutiene, V.,Zubriene, A.,Kairys, V.,Smirnov, A.,Smirnoviene, J.,Leitans, J.,Kazaks, A.,Tars, K.,Manakova, L.,Grazulis, S.,Matulis, D. Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle. Biophys.J., 119:1513-1524, 2020 Cited by PubMed: 32971003DOI: 10.1016/j.bpj.2020.08.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report