6T4O
Human Carbonic anhydrase II bound by 3,5-dimethylbenzenesulfonamide
Summary for 6T4O
| Entry DOI | 10.2210/pdb6t4o/pdb |
| Related | 6T4N |
| Descriptor | carbonic anhydrase 2, ZINC ION, BICINE, ... (6 entities in total) |
| Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29781.02 |
| Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2019-10-14, release date: 2020-10-14, Last modification date: 2024-01-24) |
| Primary citation | Dudutiene, V.,Zubriene, A.,Kairys, V.,Smirnov, A.,Smirnoviene, J.,Leitans, J.,Kazaks, A.,Tars, K.,Manakova, L.,Grazulis, S.,Matulis, D. Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle. Biophys.J., 119:1513-1524, 2020 Cited by PubMed: 32971003DOI: 10.1016/j.bpj.2020.08.037 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.133 Å) |
Structure validation
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