6SYW

human Aldose Reductase in complex with SAR25

Summary for 6SYW

• Entry DOI: 10.2210/pdb6syw/pdb
• Related: 4QBX 4YS1
• Descriptor: aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ... (5 entities in total)
• Functional Keywords: diabetes, oxidoreductase, transient binding pocket, diabetic late effects, polyol pathway, osmotic and oxidative stress, cofactor, nadph, nadp+, akr1b1, aldr1, alr2
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 37101.12

Authors

Sandner, A.,Heine, A.,Klebe, G. (deposition date: 2019-10-01, release date: 2020-10-14, Last modification date: 2024-01-24)

• Primary citation: Sandner, A.,Heine, A.,Klebe, G.,Diederich, W.,Scheer, F.M.; human Aldose Reductase in complex with SAR25; To Be Published,

Experimental method

X-RAY DIFFRACTION (0.93 Å)