6SYP

Human DHODH bound to inhibitor IPP/CNRS-A017

This is a non-PDB format compatible entry.

Summary for 6SYP

• Entry DOI: 10.2210/pdb6syp/pdb
• Descriptor: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (6 entities in total)
• Functional Keywords: dihydroorotate dehydrogenase inhibitor complex, structural genomics, structural genomics consortium, sgc, oxidoreductase
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 44041.10

Authors

Kraemer, A.,Janin, Y.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-09-30, release date: 2019-10-09, Last modification date: 2024-12-04)

• Primary citation: Kramer, A.,Tjaden, A.,Ndreshkjana, B.,Tredup, C.,Farin, H.F.,Knapp, S.,Janin, Y.L.,Muller, S.; IPP/CNRS-A017: A chemical probe for human dihydroorotate dehydrogenase (hDHODH); Curr Res Chem Biol, 2:100034-, 2022; DOI: 10.1016/j.crchbi.2022.100034

Experimental method

X-RAY DIFFRACTION (1.8 Å)