6SY7

Structure of Trypanosome Brucei Phosphofructokinase in complex with AMP.

Summary for 6SY7

• Entry DOI: 10.2210/pdb6sy7/pdb
• Descriptor: ATP-dependent 6-phosphofructokinase, BENZENE, GLYCEROL, ... (5 entities in total)
• Functional Keywords: glycolysis, amp, allostery, transferase
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 8
• Total formula weight: 432886.20

Authors

McNae, I.W.,Vasquez-Valdivieso, M.G.,Walkinshaw, M.D. (deposition date: 2019-09-27, release date: 2019-12-25, Last modification date: 2024-01-24)

• Primary citation: Fernandes, P.M.,Kinkead, J.,McNae, I.W.,Vasquez-Valdivieso, M.,Wear, M.A.,Michels, P.A.M.,Walkinshaw, M.D.; Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis.; Febs J., 287:2847-2861, 2020; PubMed: 31838765; DOI: 10.1111/febs.15177

Experimental method

X-RAY DIFFRACTION (2.75 Å)