6SWU

Crystal structure of the TPR domain of KLC1 in complex with an engineered high-affinity cargo peptide.

Summary for 6SWU

Entry DOI	10.2210/pdb6swu/pdb
Descriptor	Kinesin light chain 1,Kinesin light chain 1,TPR domain of kinesin light chain 1 in complex with an engineered high-affinity cargo peptide of sequence TVFTTEDIYEWDDSAI, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	protein complex, protein engineering, motor protein, cargo recognition
Biological source	Mus musculus (House mouse) More
Total number of polymer chains	6
Total formula weight	228275.20
Authors	Chegkazi, M.S.,Steiner, R.A. (deposition date: 2019-09-23, release date: 2020-09-30, Last modification date: 2024-01-24)
Primary citation	Cross, J.A.,Chegkazi, M.S.,Steiner, R.A.,Woolfson, D.N.,Dodding, M.P. Fragment-linking peptide design yields a high-affinity ligand for microtubule-based transport. Cell Chem Biol, 28:1347-, 2021 Cited by PubMed: 33838110 DOI: 10.1016/j.chembiol.2021.03.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.849 Å)

Structure validation