6SVQ

Crystal structure of human GFAT-1 G461E after UDP-GlcNAc soaking

Summary for 6SVQ

Entry DOI	10.2210/pdb6svq/pdb
Descriptor	Glutamine--fructose-6-phosphate-aminotransferase [isomerizing] 1, GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, ... (4 entities in total)
Functional Keywords	glutamine fructose-6-phosphate aminotransferase, gfat, ntn hydrolase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	156203.54
Authors	Ruegenberg, S.,Horn, M.,Pichlo, C.,Allmeroth, K.,Baumann, U.,Denzel, M.S. (deposition date: 2019-09-18, release date: 2020-01-15, Last modification date: 2024-01-24)
Primary citation	Ruegenberg, S.,Horn, M.,Pichlo, C.,Allmeroth, K.,Baumann, U.,Denzel, M.S. Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11:687-687, 2020 Cited by PubMed: 32019926 DOI: 10.1038/s41467-020-14524-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.717 Å)

Structure validation