6SVO
Crystal structure of human GFAT-1 in complex with Glucosamine-6-Phosphate and L-Glu
Summary for 6SVO
Entry DOI | 10.2210/pdb6svo/pdb |
Descriptor | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, 2-DEOXY-2-AMINO GLUCITOL-6-PHOSPHATE, GLUTAMIC ACID, ... (4 entities in total) |
Functional Keywords | glutamine fructose-6-phosphate aminotransferase, gfat, ntn hydrolase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 156221.43 |
Authors | Ruegenberg, S.,Horn, M.,Pichlo, C.,Allmeroth, K.,Baumann, U.,Denzel, M.S. (deposition date: 2019-09-18, release date: 2020-01-15, Last modification date: 2024-01-24) |
Primary citation | Ruegenberg, S.,Horn, M.,Pichlo, C.,Allmeroth, K.,Baumann, U.,Denzel, M.S. Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11:687-687, 2020 Cited by PubMed: 32019926DOI: 10.1038/s41467-020-14524-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.328 Å) |
Structure validation
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