6SUH

Crystal structure of human transthyretin in complex with 3-O-methyltolcapone, a tolcapone analogue

6SUH の概要

• エントリーDOI: 10.2210/pdb6suh/pdb
• 分子名称: Transthyretin, 3-O-methyltolcapone (3 entities in total)
• 機能のキーワード: amyloidosis, tetramer, binding protein, transport protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32384.50

構造登録者

Loconte, V.,Cianci, M.,Menozzi, I.,Sbravati, D.,Sansone, F.,Casnati, A.,Berni, R. (登録日: 2019-09-14, 公開日: 2020-08-05, 最終更新日: 2024-01-24)

• 主引用文献: Loconte, V.,Cianci, M.,Menozzi, I.,Sbravati, D.,Sansone, F.,Casnati, A.,Berni, R.; Interactions of tolcapone analogues as stabilizers of the amyloidogenic protein transthyretin.; Bioorg.Chem., 103:104144-104144, 2020; PubMed: 32791384; DOI: 10.1016/j.bioorg.2020.104144

実験手法

X-RAY DIFFRACTION (1.26 Å)