6SPY
Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 6-(morpholin-4-yl)pyridine-3-carboxamide
Summary for 6SPY
Entry DOI | 10.2210/pdb6spy/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, 6-morpholin-4-ylpyridine-3-carboxamide, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase |
Biological source | Cricetulus griseus (Chinese hamster) |
Total number of polymer chains | 1 |
Total formula weight | 41517.30 |
Authors | Oebbeke, M.,Siefker, C.,Heine, A.,Klebe, G. (deposition date: 2019-09-03, release date: 2020-09-30, Last modification date: 2024-01-24) |
Primary citation | Oebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G. Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60:252-258, 2021 Cited by PubMed: 33021032DOI: 10.1002/anie.202011295 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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