6SJM

Crystal structure of the Retinoic Acid Receptor alpha in complex with compound 24 (JP175)

Summary for 6SJM

Entry DOI	10.2210/pdb6sjm/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 2-[4-[3,5-bis(trifluoromethyl)phenyl]phenyl]ethanoic acid, ... (4 entities in total)
Functional Keywords	rxra, steroid hormone receptor, inhibitor, structural genomics, structural genomics consortium, sgc, dna binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	27909.27
Authors	Chaikuad, A.,Pollinger, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-08-13, release date: 2019-09-18, Last modification date: 2024-01-24)
Primary citation	Pollinger, J.,Schierle, S.,Gellrich, L.,Ohrndorf, J.,Kaiser, A.,Heitel, P.,Chaikuad, A.,Knapp, S.,Merk, D. A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences. Acs Med.Chem.Lett., 10:1346-1352, 2019 Cited by PubMed: 31531208 DOI: 10.1021/acsmedchemlett.9b00306 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.52 Å)

Structure validation