6SJM
Crystal structure of the Retinoic Acid Receptor alpha in complex with compound 24 (JP175)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Retinoic acid receptor RXR-alpha | polymer | 230 | 25818.0 | 1 | UniProt (P19793) Pfam (PF00104) In PDB | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
2 | B | Nuclear receptor coactivator 2 | polymer | 14 | 1743.0 | 1 | UniProt (Q15596) In PDB | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
3 | A | 2-[4-[3,5-bis(trifluoromethyl)phenyl]phenyl]ethanoic acid | non-polymer | 348.2 | 1 | Chemie (LFZ) | |||
4 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 229 - 456 (UniProt: P19793)
B: 471 - 484 (UniProt: Q15596)
PDB | External Database | Details |
---|---|---|
Ser 227 | - | expression tag |
Met 228 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Tyr 484 | Ser 699 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 27561.0 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 348.2 | |
All* | Total formula weight | 27909.3 |