6SJ7
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam
Summary for 6SJ7
Entry DOI | 10.2210/pdb6sj7/pdb |
EMDB information | 10213 |
Descriptor | DDB1- and CUL4-associated factor 15, DNA damage-binding protein 1, RNA binding protein 39, ... (5 entities in total) |
Functional Keywords | ddb1, oncoprotein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 214856.12 |
Authors | Srinivas, H. (deposition date: 2019-08-12, release date: 2019-12-18, Last modification date: 2019-12-25) |
Primary citation | Bussiere, D.E.,Xie, L.,Srinivas, H.,Shu, W.,Burke, A.,Be, C.,Zhao, J.,Godbole, A.,King, D.,Karki, R.G.,Hornak, V.,Xu, F.,Cobb, J.,Carte, N.,Frank, A.O.,Frommlet, A.,Graff, P.,Knapp, M.,Fazal, A.,Okram, B.,Jiang, S.,Michellys, P.Y.,Beckwith, R.,Voshol, H.,Wiesmann, C.,Solomon, J.M.,Paulk, J. Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16:15-23, 2020 Cited by PubMed: 31819272DOI: 10.1038/s41589-019-0411-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.54 Å) |
Structure validation
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